Improving Compound Quality: Physical Chemistry and DMPK Properties in Drug Discovery.
Principles, Assays and Predictions
Castle "Oud Poelgeest", Oegstgeest, The Netherlands October 21-24, 2012
Introduction – The Importance of Drug Metabolism in Drug Discovery and Development
Assays in Drug Metabolism and their Use/Interpretation
Coffee Break
Basic PK Principles Including Tutorial on PK
Lunch
Physicochemistry and Tutorial on ADME Physicochemistry
Coffee Break
Oral Absorption and Oral Bioavailability
Close
Tutorial on Oral Absorption and Bioavailability
Coffee Break
Drug Distribution Including Tutorial on Free Drug Hypothesis and Dose Prediction
Lunch
Overview of Drug Metabolizing Enzymes and Role in Clearance - Interactive Session (combining lecture and tutorial)
Coffee Break
Overview of Drug Transporters and Role in Clearance - Interactive Session (combining lecture and tutorial)
Short Tutorial on Drug Clearance
Close
Pharmacokinetic Pharmacodynamic Relationships
Coffee Break
Tutorial on Pharmacokinetic Pharmacodynamic Relationships
How Does DM fit all Together at Registration?
Wrap up and lunch