6th EFMC Short Course on Medicinal Chemistry - Fall 2012

Improving Compound Quality: Physical Chemistry and DMPK Properties in Drug Discovery.
Principles, Assays and Predictions

 Castle "Oud Poelgeest", Oegstgeest, The Netherlands    October 21-24, 2012

Programme


08:30

Introduction – The Importance of Drug Metabolism in Drug Discovery and Development

Dr Kevin BEAUMONT
PFIZER, Cambridge, United Kingdom
09:00

Assays in Drug Metabolism and their Use/Interpretation

Dr Kevin BEAUMONT
PFIZER, Cambridge, United Kingdom
10:00

Coffee Break

10:30

Basic PK Principles Including Tutorial on PK

Dr Anthony HARRISON
HOFFMANN-LA ROCHE , Basel, Switzerland
12:30

Lunch

13:30

Physicochemistry and Tutorial on ADME Physicochemistry

Dr Kevin BEAUMONT
PFIZER, Cambridge, United Kingdom
15:30

Coffee Break

16:00

Oral Absorption and Oral Bioavailability

Dr Christopher KOHL
ACTELION PHARMACEUTICALS LTD., Allschwil, Switzerland
17:30

Close

08:30

Tutorial on Oral Absorption and Bioavailability

Dr Christopher KOHL
ACTELION PHARMACEUTICALS LTD., Allschwil, Switzerland
10:00

Coffee Break

10:30

Drug Distribution Including Tutorial on Free Drug Hypothesis and Dose Prediction

Dr Kevin BEAUMONT
PFIZER, Cambridge, United Kingdom
12:30

Lunch

13:30

Overview of Drug Metabolizing Enzymes and Role in Clearance - Interactive Session (combining lecture and tutorial)

Dr Anthony HARRISON
HOFFMANN-LA ROCHE , Basel, Switzerland
15:00

Coffee Break

15:30

Overview of Drug Transporters and Role in Clearance - Interactive Session (combining lecture and tutorial)

Dr Katherine FENNER
ASTRAZENECA, Macclesfield, United Kingdom
17:00

Short Tutorial on Drug Clearance

Dr Katherine FENNER
ASTRAZENECA, Macclesfield, United Kingdom
Dr Anthony HARRISON
HOFFMANN-LA ROCHE , Basel, Switzerland
17:30

Close

08:30

Pharmacokinetic Pharmacodynamic Relationships

Dr Robert WEBSTER
PFIZER, Sandwich, Kent, United Kingdom
10:30

Coffee Break

11:00

Tutorial on Pharmacokinetic Pharmacodynamic Relationships

Dr Robert WEBSTER
PFIZER, Sandwich, Kent, United Kingdom
11:30

How Does DM fit all Together at Registration?

Dr Angus NEDDERMAN
UNILABS, York, United Kingdom
12:30

Wrap up and lunch