SPICA 2012

International Symposium on Preparative and Industrial Chromatography and Allied Techniques

 Brussels, Belgium    September 30

Programme


13:00

Registration

14:00

Start of sessions

Workshop 1
Workshop 2
Workshop 3
Workshop 1
14:00
Preparative HPLC : Phase Screening, Method Optimization, Process Development. Troubleshooting a Preparative Chromatographic Device
Dr Michael SCHULTE
MERCK, Darmstadt, Germany
Workshop 2
14:00
From Development to Commercial Scale: Rules to Scale up, QbD, Regulatory, Process Validation
Dr Alessandro BUTTE
ETH ZURICH, Zurich, Switzerland
Workshop 3
14:00
Multicolumn Processes: from Historical SMB to the Latest Advances in the Purification of Biomolecules
Prof. Arvind RAJENDRAN
UNIVERSITY OF ALBERTA, Edmonton, AB, Canada
15:30

Coffee Break

16:00

Start of sessions

Workshop 4
Workshop 5
Workshop 6
Workshop 4
16:00
Solving a Purification Process: Choice of the Appropriate Process (Batch vs Continuous, Low Pressure vs High Pressure, Liquid vs SFC, Centrifugal Partition Chromatography vs Countercurrent Chromatography)
Dr Eric VALERY
NOVASEP, Pompey, France
Workshop 5
16:00
Process Design for Purification of Small Molecules
Prof. Jochen STRUBE
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
Workshop 6
16:00
Process Design for Purification of Biomolecules
Prof. Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES, Vienna, Austria
18:00

Welcome reception

09:00

Welcome

Session 1: Quality by Design

Session Chair

Prof. Massimo MORBIDELLI
ETH ZÜRICH, Zürich, Switzerland

09:20

Quality by Design in API Purifications. Making the Right Things

Dr Alessandro BUTTE
ETH ZURICH, Zurich, Switzerland

10:00

Quality by Design with Rigorous Process Modeling as Platform Technology of the Future

Mr Christoph HELLING
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany

10:20

A Model Based Approach to Reducing the Analytical Burden of High Throughput Screening

Dr Marcus DEGERMAN
LUND UNIVERSITY, Lund, Sweden

10:40

Characterization of Adsorption in SFC: an Evaluation of Methods Used in LC

Prof. Torgny FORNSTEDT
KARLSTAD UNIVERSITY, Karlstad, Sweden

11:00

Coffee Break

Session 2: Multicolumn Chromatography

Session Chair

Dr Eric FRANCOTTE
NOVARTIS, Nuglar, Switzerland

11:30

Experimental Study on a Binary Chromatographic System Subject to a Mixed Competitive-Cooperative Adsorption Isotherm

Mr Simon JERMANN
ETH ZÜRICH, Zurich, Switzerland

11:50

Relay SMB: A Simple and Efficient Way of Implementing Simulated Moving-Bed Chromatography

Prof. José Paulo MOTA
REQUIMTE/CQFB, FFCT, Caparica, Portugal

12:10

Model Mismatch Resolution and Optimization for Simulated Moving Bed and Continuous Chromatographic Processes

Prof. Yoshiaki KAWAJIRI
GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States

12:30

Lunch, Vendor Seminar (Novasep, Waters, Phenomenex, Knauer)

Session 3: Innovative Production Technologies

Session Chair

Prof. Andreas SEIDEL-MORGENSTERN
MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany
Prof. Tuomo SAINIO
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland

14:00

Biological Production of Peptides

Prof. Susanna LEONG
NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, Singapore

14:40

Nanofiltration of Peptides in Acetonitrile/Water Mixtures: Process Development

Ms Patrizia MARCHETTI
LONZA, Visp, Switzerland

15:00

Efficient API Purification or How Combining OSN and Chromatography Increases Your Process Yields!

Dr Muriel NASSO
EVONIK, Wembley, United Kingdom

15:20

Separation of Bionanoparticles and Biological Superstructures

Prof. Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES, Vienna, Austria

15:40

Coffee Break

Session 4: Fundamentals

Session Chair

Prof. Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES, Vienna, Austria

16:10

Molecular Engineering of Multiple Weak Interactions for High Selectivity Bioseparations

Prof. Steven CRAMER M
RENSSELAER POLYTECHNIC INSTITUTE, Troy, United States

16:50

Modeling of Protein Aggregation in Preparative Chromatography

Prof. Bernt NILSSON
LUND UNIVERSITY, Lund, Sweden

17:10

Modeling Protein Adsorption Equilibria on Ion-Exchange Resins

Dr Bertrand GUELAT
NOVARTIS PHARMA AG, Basel, Switzerland

17:30

Distributed Pore Surface Model

Ing Niklas BORG
LUND UNIVERSITY, Lund, Sweden

17:50

Study of Hydrodynamics in Chromatographic Columns by Computed X-Ray Tomography and its Evaluation by CFD Simulations

Ms Irma SCHMIDT
UNIVERSITY ERLANGEN-NUREMBERG, Erlangen, Germany

18:10

Poster Session #1

07:00

Young Scientist Breakfast

Session 5: Green Technology - Complex Continuous Resolution

Session Chair

Prof. Arvind RAJENDRAN
UNIVERSITY OF ALBERTA, Edmonton, AB, Canada
Dr Svetlana IGNATOVA
BRUNEL UNIVERSITY, Uxbridge, United Kingdom

08:50

Preparative Chiral Chromatography: What Can Go Wrong and How to Solve it

Dr Pilar FRANCO
CHIRAL TECHNOLOGIES, INC, Illkirch, France

09:10

Supercritical Fluids as the Desorbent for Simulated Moving Bed? Application to the Concentration of Triterpenoids from Taiwanofugus Camphorate

Ms Liang RU CHIEN
I SHOU UNIVERSITY, Kaohsiung City, Taiwan

09:30

Optimization of Simulated Moving Bed Processes for Multicomponent Chiral Separations

Dr António E. RIBEIRO
POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal

09:50

A Non-Conventional Application of Simulated Moving Bed Technology: Purification of a Complex Mixture

Ms Kiara KOCHENDOERFER
UNIVERSITY ERLANGEN-NUREMBERG, Ludwigshafen, Germany

10:10

Coffee Break

Session 6: Partitioning and Extraction

Session Chair

Prof. Joachim KINKEL
GEORG-SIMON-OHM UNIVERSITY OF APPLIED SCIENCES, Nuernberg, Germany

10:40

Liquid-Liquid Extraction of Biomolecules - Process Development and Integration into Downstream Processing

Mr Jan Kristof EGGERSGLUESS
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal, Germany

11:00

Design Of Tailor-Made Stationary And Mobile Phase In Liquid-Liquid Chromatography

Prof. Mirjana MINCEVA
UNIVERSITÄT ERLANGEN, Freising, Germany

11:20

Towards Optimally Sized Centrifugal Partition Chromatography Columns - Process Design Methodology and Applications

Mr Sebastien CHOLLET
GEPEA LABORATORY, Saint-Nazaire, France

11:40

Scalable Technology for the Extraction of Pharmaceuticals (STEP): Progress on Developing Versatile Small Footprint Technology for Continuous Processing at the Lab Scale up to 1 Kg/Day

Prof. Ian SUTHERLAND
BRUNEL INSTITUTE FOR BIOENGINEERING, Uxbridge, United Kingdom
Dr Svetlana IGNATOVA
BRUNEL UNIVERSITY, Uxbridge, United Kingdom

12:00

Lunch, Vendor Seminar (Kromasil, Merck Millipore, PIC Solution and Chiral Technologies)

Session 7: Process Integration 1 - Isomeric Separation

Session Chair

Dr Shalini ANDERSSON
ASTRAZENECA, Mölndal, Sweden
Prof. Mirjana MINCEVA
UNIVERSITÄT ERLANGEN, Freising, Germany

13:30

Implementation of a Continuous Chromatography Step in The Synthesis of an API – Combining Chemistry and Chromatography to Achieve Better Economics

Dr Olivier DAPREMONT
AMPAC FINE CHEMICALS, Rancho Cordova, United States

14:10

Continuous Synthesis and Purification Through Direct Combination of a Flow Reactor and Simulated Moving Bed Chromatography

Dr Ju Weon LEE
MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany

14:30

Integrated Chromatographic Processes for the Production of Pure Enantiomers

Prof. Malte KASPEREIT
FRIEDRICH-ALEXANDER UNIVERSITY ERLANGEN-NÜRNBERG, Erlangen, Germany

14:50

From Racemate to Single Enantiomer with 100% Yield by Process Integration of SMB and Enzymatic Racemization

Mr Markus FUEREDER
ETH ZURICH, Basel, Switzerland

15:10

Coffee Break sponsored by AMPAC Fine Chemicals

Session 8: Process Integration 2 - Food and Products

Session Chair

Dr Eric VALERY
NOVASEP, Pompey, France
Prof. Malte KASPEREIT
FRIEDRICH-ALEXANDER UNIVERSITY ERLANGEN-NÜRNBERG, Erlangen, Germany

15:40

New Approaches to Food Fractionation by Chromatography: Adapting High-Cost Techniques to the Production of Moderate-Value Products

Prof. Conan FEE
UNIVERSITY OF CANTERBURY, Christchurch, New Zealand

16:20

A Reaction-Separation Integrated Process for the High-Yield Synthesis of Rare Sugars

Ms Nina WAGNER
ETH ZURICH D-BSSE, Basel, Switzerland

16:40

Chromatographic Process Options for Reduced Purities

Prof. Tuomo SAINIO
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland

17:00

Model Based Design and Integration of Crystallization Processes of Natural Products in Down Stream Processing

Mr Iraj KOUDOUS
INSITUT FÜR THERMISCHE VERFAHRENS- UND PROZESSTECHNIK, Clausthal-Zellerfeld, Germany

17:20

Special Symposium - Rountable Discussion: Process Integration and Intensification

Dr Olivier DAPREMONT
AMPAC FINE CHEMICALS, Rancho Cordova, United States


Dr Eric VALERY
NOVASEP, Pompey, France
Dr Shalini ANDERSSON
ASTRAZENECA, Mölndal, Sweden

18:00

Poster Session 2

20:00

Gala Dinner

Session 9: SMB and Novel Chromatography Approaches

Session Chair

Prof. José Paulo MOTA
REQUIMTE/CQFB, FFCT, Caparica, Portugal

08:50

Enabling High Purities and Yields in Therapeutic Peptide Purification by Using Continuous Chromatography (MCSGP)

Dr Thomas MÜLLER-SPÄTH
CHROMACON AG, Zurich, Switzerland

09:10

Continuous Purification of Single-Chain Antibody Fragments by Simulated Moving Bed Chromatography

Mr Carlos Andres MARTINEZ CRISTANCHO
MAX-PLANCK-INSTITUT MAGDEBURG, Magdeburg, Germany

09:30

Integration of Hydrophobic Interaction- and Ion Exchange Chromatography

Mr Tim WELLSANDT
INSITUT FÜR THERMISCHE VERFAHRENS- UND PROZESSTECHNIK, Clausthal-Zellerfeld, Germany

09:50

Purification of Proteins from Human Blood Plasma by Multicolumn Solvent Gradient Purification

Mr Daniel BAUR
ETH ZÜRICH, Zurich, Switzerland

10:10

Poster Prize

10:30

Coffee Break

Session 10: Affinity Ligands and Biopharmaceuticals

Session Chair

Prof. Jochen STRUBE
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany

11:00

Molecular Modeling of the Affinity Chromatography of Proteins: Status and Perspectives

Prof. Carlo CAVALLOTTI
POLITECNICO DI MILANO, Milano, Italy

11:40

Peptidomimetic Affinity Ligands (PALs) - A Powerful Approach to Improving DSP Performance

Dr Matthias PASCHKE
3B PHARMACEUTICALS GMBH, Berlin, Germany

12:00

New Trend in Material Development for Peptide Purification

Dr Nicola FORRER
ZEOCHEM, Uetikon am See, Switzerland

12:20

A New Disposable Technology for Chromatographic Purification of Biopharmaceuticals

Dr David YAVORSKY
MERCK-MILLIPORE, Bedford, United States

12:40

Shifting the Scale-up Limits of Disposable Downstream Processing

Mr. Marcel RAEDTS
PROXCYS BV, Nieuw Amsterdam, The Netherlands

13:00

Closing Remarks