RICT 2011 - Drug Discovery and Selection

47th International Conference on Medicinal Chemistry
47e Rencontres Internationales de Chimie Thérapeutique

 Lyon, France    July 6-8, 2011

Programme


08:00

Registration

09:15

Welcome Session

Session 1: Case Studies

Session Chair

Prof. Pascal DUMY
ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE MONTPELLIER (ENSCM), Montpellier, France

09:30

Discovery of Riociguat: A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

Prof. Joachim MITTENDORF
BAYER SCHERING PHARMA, Wuppertal, Germany

10:15

Aleglitazar, a Potent and Balanced Dual PPARα/γ Agonist for the Reduction of Cardiovascular Mortality and Morbidity in Patients with Type 2 Diabetes

Dr Peter MOHR
F. HOFFMANN-LA ROCHE, Basel, Switzerland

11:00

Coffee Break

Session Chair

Dr Edmond DIFFERDING
DIFFERDING CONSULTING, Louvain-la-Neuve, Belgium

11:30

Discovery of Potent and Selective Smoothened Inhibitors for the Treatment of Hedgehog-dependent Tumors

Dr Stefan PEUKERT
NOVARTIS, Cambridge MA, United States

12:15

Gut-Targeted Microsomal Triglyceride Transfer Protein Inhibitors to Treat Obesity: Design, Clinical Proof of Concept and Novel Chemical Leads

Dr Lieven MEERPOEL
JANSSEN R&D, Beerse, Belgium

13:00

Lunch and Poster Session

Session 2: From Screening to Development

Session Chair

Prof. Pierre-Alain CARRUPT
UNIVERSITÉ DE GENÈVE, Geneva 4, Switzerland

14:30

Discovery and Optimization of Kinase Inhibitors: Some Case Studies from GKS3β and IGF1R Inhibitors

Dr Dominique LESUISSE
SANOFI, Chilly-Mazarin, France

15:15

Discovery and Lead Optimisation of a Novel Series of Highly Potent, Selective and Orally Bioavailable SYK Inhibitors

Dr Neil GARTON
GLAXOSMITHKLINE, Stevenage, United Kingdom

16:00

Coffee Break and Poster Session

Session Chair

Dr Luc VAN HIJFTE
JANSSEN RESEARCH & DEVELOPMENT, Nijmegen, The Netherlands

16:30

The Design, SAR and Synthesis of Novel ADAM-TS4 (Aggrecanase-1) Inhibitors for the Treatment of Osteoarthritis

Dr Chris DE SAVI
ASTRAZENECA R&D, Boston, United States

17:15

Ehrlich Lecture - Title to be announced

Prof. Jean MARTINEZ
UNIVERSITY OF MONTPELLIER, Montpellier, France

18:00

Final Announcements

18:30

Welcome drink sponsored by BIOalternatives

09:45

Start of sessions

Session 3: Other Innovative Approaches
Session 3: Other Innovative Approaches
Session Chair
Prof. Jens HASSERODT
ENS, Lyon, France
10:30

Coffee Break and Poster Session

11:45

Start of sessions

Session 3: Other Innovative Approaches (Fol.)
Session 4: In Silico Approaches
Session 3: Other Innovative Approaches (Fol.)
Session Chair
Dr Pascal GEORGE
SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France
Session 4: In Silico Approaches
Session Chair
Dr Solo GOLDSTEIN
INSTITUT DE RECHERCHES SERVIER, Suresnes, France
12:30

Lunch and Poster Session

14:45

Start of sessions

Session 5: Hit to Lead
Session 6: Fluorine in Medicinal Chemistry
Session 5: Hit to Lead
Session Chair
Dr Olivier LAVERGNE
., Palaiseau, France
Session 6: Fluorine in Medicinal Chemistry
Session Chair
Dr Frédéric DOLLE
CEA, SERVICE HOSPITALIER FRÉDÉRIC JOLIOT, Orsay, France
15:30

Coffee Break and Poster Session

16:15

Start of sessions

Session 5: Hit to Lead (Fol.)
Session 6: Fluorine in Medicinal Chemistry (Fol.)
Session 5: Hit to Lead (Fol.)
Session Chair
Mr Jean-Claude FLORENT
INSTITUT CURIE, Paris, France
Session 6: Fluorine in Medicinal Chemistry (Fol.)
Session Chair
Dr Pascal GEORGE
SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France
17:45

Final Announcements

20:00

Gala Dinner

Session 7: New Strategies, Tools and Platforms

Session Chair

Prof. Peter GOEKJIAN
UNIVERSITE DE LYON, Villeurbanne Cedex, France

09:00

Accessing Libraries of Highly Antitumor Active Ansamycin Antibiotics by Semi- and Mutasynthesis

Prof. Andreas KIRSCHNING
LEIBNIZ UNIVERSITY, Hannover, Germany

09:45

Development of Enantiomers: the Example of Chiral Sulfoxides

Dr Philippe PITCHEN
FOREST RESEARCH INSTITUTE, Hauppauge, United States

10:30

Coffee Break and Poster Session

11:00

Poster Awards

Session 7: New Strategies, Tools and Platforms (fol)

Session Chair

Dr Michel PEREZ
PIERRE FABRE, Toulouse, France

11:30

Non-Denaturing Chemical Proteomics for Protein Complex Isolation and Identification

Dr Alain WAGNER
UNIVERSITÉ DE STRASBOURG, Illkirch, France

12:15

Mentzer Lecture - DNA-Encoded Chemical Libraries: a New Tool for Drug Discovery

Prof. Dario NERI
ETH ZÜRICH, Zürich, Switzerland

13:00

Final Conclusions

13:15

Lunch