RICT 2011 - Drug Discovery and Selection

47th International Conference on Medicinal Chemistry
47e Rencontres Internationales de Chimie Thérapeutique

 Lyon, France    July 6-8, 2011

Confirmed Speakers

A Brief Guide to Fluorine-Protein Interactions for the Medicinal Chemist

Dr Jérôme AMAUDRUT
ABBOTT-LABORATOIRE FOURNIER, Daix, France

How can Computers Support Drug Discovery? In Silico Approaches for Anticipating Bioactivity Spectra, Analysing Adverse Drug Reactions and Predicting Ligand Activity Against Particular Protein Mutants

Prof. Andreas BENDER
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

The Design, SAR and Synthesis of Novel ADAM-TS4 (Aggrecanase-1) Inhibitors for the Treatment of Osteoarthritis

Dr Chris DE SAVI
ASTRAZENECA R&D, Boston, United States

Synthesis of Radiolabelled Probes for Positron Emission Tomography: The Link Between Molecular Imaging and Medicinal Chemistry

Dr Frédéric DOLLE
CEA, SERVICE HOSPITALIER FRÉDÉRIC JOLIOT, Orsay, France

Template Assembled Functional Biomolecules : Chemistry, Characterization and Validation as a Paradigm for Tailor Made Molecular Medicine

Prof. Pascal DUMY
ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE MONTPELLIER (ENSCM), Montpellier, France

Proteomic Studies as a Guide in the Development of New Cyclin-dependent Kinase Inhibitors

Prof. Hervé GALONS
SCT & PARIS DESCARTES UNIVERSITY, Paris, France

Discovery and Lead Optimisation of a Novel Series of Highly Potent, Selective and Orally Bioavailable SYK Inhibitors

Dr Neil GARTON
GLAXOSMITHKLINE, Stevenage, United Kingdom

Folding Oligomers with Predictable Structures and Properties

Dr Ivan HUC
IECB & CNRS - UNIVERSITÉ DE BORDEAUX, Bordeaux, France

Accessing Libraries of Highly Antitumor Active Ansamycin Antibiotics by Semi- and Mutasynthesis

Prof. Andreas KIRSCHNING
LEIBNIZ UNIVERSITY, Hannover, Germany

The Mitotic Kinesin Eg5 as a Target for Drug Development in Cancer Chemotherapy: from Inhibitor Screening to in vivo Models

Prof. Frank KOZIELSKI
BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom

Fragment-based Engineering of Protein-ligand Interactions Using NMR and Other Biophysical Methods : Towards Tailor-made Drugs

Prof. Jean-Marc LANCELIN
CPE, VILLEURBANNE Cedex, France

Discovery and Optimization of Kinase Inhibitors: Some Case Studies from GKS3β and IGF1R Inhibitors

Dr Dominique LESUISSE
SANOFI, Chilly-Mazarin, France

Ehrlich Lecture - Title to be announced

Prof. Jean MARTINEZ
UNIVERSITY OF MONTPELLIER, Montpellier, France

Difluoromethylbenzoxazole (DFMB)Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Dr Maurice MEDEBIELLE
UNIVERSITÉ CLAUDE BERNARD LYON 1, Villeurbanne, France

Gut-Targeted Microsomal Triglyceride Transfer Protein Inhibitors to Treat Obesity: Design, Clinical Proof of Concept and Novel Chemical Leads

Dr Lieven MEERPOEL
JANSSEN R&D, Beerse, Belgium

Discovery of Riociguat: A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

Prof. Joachim MITTENDORF
BAYER SCHERING PHARMA, Wuppertal, Germany

Aleglitazar, a Potent and Balanced Dual PPARα/γ Agonist for the Reduction of Cardiovascular Mortality and Morbidity in Patients with Type 2 Diabetes

Dr Peter MOHR
F. HOFFMANN-LA ROCHE, Basel, Switzerland

New Multivalent Glyco-vaccines: Molecular Engineering of the Regiospecificity of Transglucosidases for Chemo-enzymatic Oligosaccharide Synthesis

Prof. Pierre MONSAN
INSA, Toulouse, France

Mentzer Lecture - DNA-Encoded Chemical Libraries: a New Tool for Drug Discovery

Prof. Dario NERI
ETH ZÜRICH, Zürich, Switzerland

KCC2 : a New Target for Epilepsy?

Dr Cécile PEGURIER
UCB PHARMA, Braine-L'Alleud, Belgium

Discovery of Potent and Selective Smoothened Inhibitors for the Treatment of Hedgehog-dependent Tumors

Dr Stefan PEUKERT
NOVARTIS, Cambridge MA, United States

Development of Enantiomers: the Example of Chiral Sulfoxides

Dr Philippe PITCHEN
FOREST RESEARCH INSTITUTE, Hauppauge, United States

Tumor Targeting Using Shiga Toxin: Syntheses and Biological Evaluations of Some Conjugates

Dr Frédéric SCHMIDT
INSTITUT CURIE, Paris, France

A Journey in Data and Chemical Spaces: Application to Pharmaceutical Sciences

Dr Philippe VAYER
LABORATOIRE SERVIER, Orléans, France

Non-Denaturing Chemical Proteomics for Protein Complex Isolation and Identification

Dr Alain WAGNER
UNIVERSITÉ DE STRASBOURG, Illkirch, France
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