LD Organisation

Scientific Conference Producers

Program

Remark:
Poster Session 1 = odd numbers
Poster Session 2 = even numbers



14:00

Registration

19:30

Welcome reception

08:30

Opening

Morning Session

Session Chair

Dr Scott A. BILLER
AGIOS PHARMACEUTICALS, Cambridge, United States

09:10

The Metalated Flatland Conduit to New Synthetic Aromatics and Heteroaromatic Chemistry

Prof. Victor SNIECKUS
QUEEN'S UNIVERSITY, Ontario, Canada

09:50

C-H Activation: Direct Arylation and Alkenylation of Oxazoles

Dr. Florence MAHUTEAU
INSTITUT CURIE, ORSAY, France

10:05

Coffee-break

10:45

Orally Active, Brain Penetrant Beta-Secretase (BACE) Inhibitors: Consolidating Property-Based and Structure-Based Drug Design

Dr. Stephen HITCHCOCK
AMGEN INC, Thousand Oaks, United States

11:25

From Structures to Systems: Structure Based Design of Therapeutics and Imaging Probes

Dr. Ulrich WENDT
SANOFI AVENTIS, Frankfurt, Germany

12:05

Structure-Activity Relationships and Cancer-Cell Selective Toxicity Of Novel Inhibitors of Glioma-Associated Oncogene Homolog 1 (Gli1)-Mediated Transcription

Dr Naoaki FUJII
ST.JUDE CHILDREN'S RESEARCH HOSPITAL, Memphis, United States

12:20

Molecular Recognition at the Active Site of Catechol-O-Methyl Transferase (COMT): Energetically Favorable Expulsion of a Single Water Molecule with Novel Bisubstrate Inhibitors.

Mr Manuel ELLERMANN
ETH ZURICH, Zurich, Switzerland

12:35

Lunch and Poster Session 1

Afternoon Session

Session Chair

Prof. Victor SNIECKUS
QUEEN'S UNIVERSITY, Ontario, Canada

14:00

Bio-Inspired Organocatalysis: From Concepts to Applications in Heterocycle Synthesis

Prof. Magnus RUEPING
RWTH AACHEN, Aachen, Germany

14:40

Discovery of Ixempratm (ixabepilone), an Epothilone Analogue for Treatment of Metastatic Breast Cancer

Dr. Gregory VITE
BMS, Princeton, United States

15:20

Design and Synthesis of Novel Polyketide Molecular Frameworks to Access Natural Product-Like Protein-Protein Interaction Inhibitors as Novel Chemotherapeutic Agents

Dr Giovanna ZINZALLA
LONDON SCHOOL OF PHARMACY, London, United Kingdom

15:35

Coffee-break and Poster Session 1

16:05

Compound Collection Enhancement (CCE): Increasing Quality and Size of the AZ Compound Collection

Dr. Kay BRICKMANN
ASTRA ZENECA, Mölndal, Sweden

16:45

Approach to the Synthesis of Pycnanthuquinone C by Gold(I)-Catalyzed Cyclization of 1,5-Enynes

Ms NURIA HUGUET
INSTITUTE OF CHEMICAL RESEARCH OF CATALONIA, Tarragona, Spain

17:25

C-H: A New Functional Group for Streamlining Synthesis

Prof. Christina WHITE
UNIVERSITY OF ILLINOIS, Urbana, United States

18:05

Closing of the day

Morning Session

Session Chair

Dr Edmond DIFFERDING
UCB, Braine-l'Alleud, Belgium

08:30

Development and Applications of New Metal-Catalyzed Carbon-Carbon Bond Forming Reactions

Prof. Jonathan A. ELLMAN
UNIVERSITY OF CALIFORNIA, Berkeley, United States

09:10

Case Histories of Fragment Based Discovery: from Crystal to Clinic

Dr David REES
ASTEX THERAPEUTICS, Cambridge, United Kingdom

09:50

Design and synthesis of polyfluoroalkyl-containing purine isosters and phospha-purines as a potential Adenosine Deaminase (ADA) and Inosine 5’-monophosphate dehydrogenase (IMPDH) inhibitors

Dr Dmytro VOLOCHNYUK
ENAMINE, Kyiv, Ukraine

10:05

Coffee-break and Poster Session 1

10:45

The Fight against AIDS. The "Old" Reverse Transcriptase (RT) and the "New" DDX3

Prof. Maurizio BOTTA
UNIVERSITY OF SIENA, Siena, Italy

11:25

Targeting Protein-Protein Interactions: Bcl-2 Family Protein Inhibitors to Treat Cancer

Dr. Steve ELMORE
ABBOTT LABORATORIES, Abbott Park, United States

12:05

Discovery Biology Fueled with Synthetic Chemicals

Prof. Patrick G. HARRAN
UNIVERSITY OF CALIFORNIA, Los Angeles, United States

12:45

Lunch & Poster session 1

14:00

Afternoon Session: Business Mini-Symposium

Session Chair

Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States

14:05

Compound Screenings in Model Plants to Identify New Agrochemicals: Strengths and Limitations

Dr. Dominique AUDENAERT
GHENT UNIVERSITY, GHENT, Belgium

14:20

Creating a medicinal chemistry created screening library

Dr. Peter BEAN
CYTOKINETICS, South San Francisco, United States

14:35

Optimization of a Small Molecule Screening Library to support HTS Campaigns Across Diverse Therapeutic Areas and Target Classes

Dr. Andrew.J. GARTON
OSI PHARMACEUTICALS, Framingdale, United States

14:50

Strategies Toward The Establishment and Evolution of a CNS Focused Small Molecule Screening Collection

Dr. Kevin HODGETTS
GALENEA, CAMBRIDGE, United States

15:05

Small Molecule Screening Libraries in Drug Discovery: Today & Tomorrow

Dr. Duncan JUDD
GLAXOSMITHKLINE, Essex, United Kingdom

15:20

JHICC - When Vast Chemical Diversity Meets Ion Channel Targets

Dr Min LI
JOHNS HOPKINS MEDICAL SCHOOL, Baltimore, United States

15:35

Coffee-break

15:50

Navigating the NIH Roadmap - Building a Screening Collection for Discovery of Biological Probes

Dr. Victor PANCHENKO
BIOFOCUS, San Francisco, United States

16:05

Kinase Inhibitors in Compound Collection of Life Chemicals

Dr. Alexander POKHOLENKO
LIFE CHEMICALS, Ukraine

16:20

Chemically Validated Combinatorial Approach to Large Libraries of Individual Drug Like Compounds

Dr. Aleksandr SHIVANYUK
MACROCHEM, Kiev, Ukraine

16:35

Scaffold-based Libraries: It’s design and applications

Dr. Bernd WENDT
EMBL HEIDELBERG, Heidelberg, Germany

16:50

Out-Sourcing Of Small Molecule Screening Libraries: Lessons From The Past, View Into The Future

Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States

17:05

Q & A

17:30

Closing of the day

Morning Session

Session Chair

Prof. Valery P. KUKHAR
INSTITUTE OF BIOORGANIC CHEMISTRY AND PETROCHEMISTRY, Kyiv, Ukraine

08:30

The Chemistry of DNA Repair and DNA Lesion Tolerance

Prof. Thomas CARELL
LUDWIG-MAXIMILIANS-UNIVERSITY MUNICH, Munich, Germany

09:10

Design of BCR-Abl Kinase Inhibitors to Treat Imatinib-Resistant Leukaemia

Dr Paul W. MANLEY
NOVARTIS PHARMA, Basel, Switzerland

09:50

SQUIRRELnovo: De Novo Design of a PPARalpha Agonist by Bioisosteric Replacement

Dr Ewgenij PROSCHAK
UNIVERSITÄT FRANKFURT, Frankfurt a. M., Germany

10:05

Coffee-break

10:45

Discovery of PF-610355: An Inhaled Once-daily Beta-2 Adrenoceptor Agonist for Asthma & COPD

Mr. Paul GLOSSOP
PFIZER GLOBAL R&D, Sandwich Kent, United Kingdom

11:25

Discovery of NVP-BEZ235, a New Anti-Cancer Drug Candidate Targeting the PI3K/Akt/mTOR Pathway

Dr. Frédéric STAUFFER
NOVARTIS INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland

12:05

Conformational Restriction as a Design Concept for Unnatural Amino Acids

Prof. Igor KOMAROV
KIEV TARAS SHEVCHENKO UNIVERSITY, Kiev, Ukraine

12:20

Directed Evolution of Enzymes: New Biocatalysts for Organic Synthesis'

Prof. Nicholas John TURNER
UNIVERSITY OF MANCHESTER, Manchester, United Kingdom

13:00

Lunch and Poster Session 2

Free afternoon

Morning Session

Session Chair

Prof. Gerhard ECKER
UNIVERSITY OF VIENNA, Vienna, Austria

08:30

A Small Molecule with a Big Impact: Inspirations from Proline Catalysis

Prof. Benjamin LIST
MAX PLANCK INSTITUT, Muelheim an der Ruhr, Germany

09:10

The Structure Based Design of Potent, Selective BACE1 Inhibitors as Potential Disease Modifying Treatments for Alzheimer's Disease

Dr Al ROBICHAUD
SAGE, Princeton, United States

09:50

Chiral Imidates: A New Class of Nitrogen-Based Chiral Ligands.

Prof. Johan VAN DER EYCKEN
UGENT, Ghent, Belgium

10:05

Coffee-break and Poster Session 2

10:45

Orexin Receptor Antagonists – A New Therapeutic Principle in CNS Disorders?

Dr Christoph BOSS
ACTELION PHARMACEUTICALS LTD, Allschwil, Switzerland

11:25

Guanidinium Toxins: Unique Natural Products in both Form and Function

Prof. Justin DU BOIS
STANFORD UNIVERSITY, Stanford, United States

12:05

Cation–Pi Interactions in the S4 Pocket of Factor Xa: Dramatic Enhancement upon N-Alkylation of Ammonium Ions

Ms Laura Maria SALONEN
ETH ZURICH, Zurich, Switzerland

12:20

Lunch and Poster Session 2

Afternoon Session

Session Chair

Prof. Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland

14:00

Small Molecule Drug Discovery in the Modern World

Dr Michael VARNEY
GENENTECH, South San Francisco, United States

14:40

Synthesis of Fluorine Containing Amino Acids with Biological Interest

Prof. Valery P. KUKHAR
INSTITUTE OF BIOORGANIC CHEMISTRY AND PETROCHEMISTRY, Kyiv, Ukraine

15:20

Building Molecular Complexity via Gold Catalysis

Prof. Antonio M. ECHAVARREN
INSTITUTE OF CHEMICAL RESEARCH OF CATALONIA (ICIQ), Tarragona, Spain

16:00

Coffee-break

16:40

The Discovery of the Oral Antifungal Agent Albaconazole: a Case History

Dr. Xavi BARTROLI
PALAU PHARMA, Palau de Plegamans, Spain

17:10

New Catalytic Strategies for Chemical Synthesis

Prof. Matthew GAUNT
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

17:50

Closing Remarks

20:00

Symposium banquet