LD Organisation

Scientific Conference Producers

Program


Optional tours between 09.00-18.00 / Pushkin (Amber room) + Pavlovsk Palaces, three Cathedrals (tbc), Canals

Transfers from the airport between 12.00-19.00

14:00

Registration

19:30

Welcome reception

08:30

Opening

09:10

The Changing Face of Organic Synthesis

Prof. Steven V. LEY
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

10:00

Protecting Group Directed Ring-Closing Metathesis (RCM): the First Total Synthesis of Anti-Malarial Nonenolide

Dr. Mukund S. CHORGHADE
CHORGHADE ENTERPRISES, NATICK, United States

10:15

Coffee-break

10:45

Discovery of Innovative Small Molecule Therapeutics

Prof Magid ABOU-GHARBIA
TEMPLE UNIVERSITY, Philadelphia, United States

11:35

The Discovery of Novel Antiviral Agents

Dr. Joe VACCA
MERCK & CO., West Point, United States

12:05

Ultra-High-Throughput Screening for Lead Discovery: Impact of Combinatorial Chemistry Compound Libraries

Dr. Stefan MUNDT
BAYER HEALTHCARE, Elberfeld, Germany

12:35

A Combinatorial Approach to Probe the Mechanism of Binding of Bivalent Ligands to GPCRs

Ms Kimberly BONGER
LEIDEN UNIVERSITY, Leiden, The Netherlands

12:50

Lunch

14:00

Polyfunctional Zn,Mg-Organometallics for Organic Synthesis

Prof. Paul KNOCHEL
LUDWIG MAXIMILIANS UNIVERSITY, Munich, Germany

14:50

Innovation in Drug Discovery and Development Interface

Dr. Balu BALASUBRAMANIAN
BRYSTOL-MYERS SQUIBB, Princeton New Jersey 08543, United States

15:20

From Adrenomedullin Positive Modulators to A New Type Of Mmp-2 Inhibitors

Prof. Beatriz DE PASCUAL-TERESA
CEU SAN PABLO UNIVERSITY, Madrid, Spain

15:35

Coffee-break

16:05

Surprises and Discoveries with Natural Products

Prof. Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland

16:55

Discovery of Bile Acid Resorption Inhibitors

17:25

Tetracyclic Indole Inhibitors of Hepatitis C Virus Ns5b-Polymerase

Dr. Ian STANSFIELD
IRBM MERCK, Pomezia Roma, Italy

17:40

Metal-Catalyzed Coupling Reactions

Prof. Gregory C. FU
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Pasadena, United States

19:30

City tour for participants

08:30

A Tale of Two Proteases

Dr Scott A. BILLER
NOVARTIS, Cambridge, United States

09:20

Positive and Negative Modulation of Family C GPCRs

Prof. Tanja WEIL
MERZ PHARMACEUTICALS, Ulm, Germany

09:50

New Sugar-Derived Compounds with Anti-Septic Shock, Anti-Inflammatory and Anti-Ischemia Activity

Dr. Francesco PERI
UNIVERSITY OF MILANO/BICOCCA, Milano, Italy

10:05

Coffee-break

10:35

Genomic and Nongenomic Bile Acid Receptors as New Targets for Drug Discovery

Prof. Roberto PELLICCIARI
UNIVERSITY OF PERUGIA & EFMC, Corciano, Italy

11:25

The Identification of Secretase Inhibitors for the Treatment of Alzheimer's Disease

Dr. John ELLINGBOE
WYETH RESEARCH, Pearl River, United States

11:55

Where Chemistry meets Sphingolipid Biology

12:25

Synthesis of Fosmidomycin Analogues Modified at the Three-Carbon Spacer: Towards Potent Antimalarials

Prof. Serge VAN CALENBERGH
UGENT, Ghent, Belgium

12:40

Lunch & Poster session

BUSINESS MINI SYMPOSIUM: Discovery Chemistry Outsourcing Opportunities in Russia

14:00

Opening

Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States

A Renewed Emphasis on Partnerships, With a Twist; The Challenge to Meet the Ever Evolving Pharma Landscape

Dr. Michael CLARK
PFIZER, New London, United States

Discovery Chemistry Sourcing in Russia. How Does it Compare to Other Regions of the World?

Dr. Richard D. CONNELL
PFIZER, Groton, United States

Outsourcing Parts of the Discovery Value Chain in Russia

Dr Frederik DEROOSE
JOHNSON & JOHNSON PHARMACEUTICALS, Destelbergen, Belgium

The AstraZeneca Compound Collection Enhancement Programme - Outsourcing in Russia

Dr. Garry PAIRAUDEAU
ASTRAZENECA R&D MÖLNDAL, Möndal, Sweden

Outsourcing in Russia: the UCB Experience

Dr. Patrice TALAGA
UCB, Braine-L'Alleud, Belgium

Discovery Chemistry CROs: The Art of Playing on the Fast Changing Field

Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States

16:05

Coffee-break

Panel discussion participants

B. BALASUBRAMANIAN (BMS, US), M. CLARK (Pfizer, US), R.D. CONNELL (Pfizer, US), F. DEROOSE (J&J Pharmaceuticals, Belgium), D. STOUT (Merck, US), W.B. KNIGHT (GSK, US), G. PAIRAUDEAU (AstraZeneca, UK), P. TALAGA (UCB, Belgium), G. VAISBERG (ChemBridge)

19:00

City tour for participants

08:30

New Approaches to Biologically Validated Molecules using Chemoselective Ligation Reactions

Prof. Alessandro DONDONI
UNIVERSITY OF FERRARA, Ferrara, Italy

09:20

Discovery of Aclidinium Bromide, a New Long-Acting Muscarinic Antagonist for COPD Therapy

Dr. Hamish RYDER
ALMIRALL, Barcelona, Spain

09:50

Novel Multilabeled Oligonucleotides Containing 1-phenylethynylpyrene ara-2´-uridine-carbamate and LNA: Synthesis and Photochemical Properties

Dr. Irina ASTAKHOVA
NUCLEIC ACID CENTER, DEPARTMENT OF PHYSICS AND CHEMISTRY, Odense M, Denmark

10:05

Coffee-break

10:35

Modern Protein Chemistry

Prof. Ron RAINES
UNIVERSITY OF WISCONSIN, Madison, United States

11:25

Exploiting High Throughput Screening: Case Histories

Dr Paul LEESON
, Nuneaton, United Kingdom

11:55

Design and Synthesis of Thrombin Receptor Antagonists for the Prevention of Thrombosis

Dr William J. GREENLEE
SCHERING-PLOUGH RESEARCH INSTITUTE, United States

12:45

Lunch

Free afternoon - optional tours to Hermitage, Russian Museum, 3 Cathedrals and Canals

08:30

Chemical Probes of Carbohydrate Biosynthetic Pathways in Mycobacterium Tuberculosis

Prof. Laura KIESSLING
UNIVERSITY OF WISCONSIN-MADISON, Madison, United States

09:20

Discovery and Development of Kinase Iinhibitors by Targeting Conformational Switch Pockets. A General Platform that is Unique for Targeting ATP Pockets

Dr. Peter A. PETILLO
DECIPHERA PHARMACEUTICALS, Lawrence, United States

09:50

Synthesis of (±)-Cephalotaxine via Diallylboration-Ring Closing Metathesis-Bromocyclocarbamation Sequence

Dr Nikolai KUZNETSOV
INEOS RAS, Moscow, Russia

10:05

Coffee-break

10:35

SAHA (Vorinostat), an FDA Aapproved Anticancer Compound with a Novel Mechanism of Action

Prof. Ronald BRESLOW
COLUMBIA UNIVERSITY, New York, United States

11:25

The Fight Against AIDS: New Avenues for Inhibiting RT, an Old Target

Prof. Maurizio BOTTA
UNIVERSITY OF SIENA, Siena, Italy

11:55

Adventures in Medicinal Chemistry

Dr Anthony WOOD
PFIZER, Waltham, United States

12:25

Smiles Rearrangement and Isocyanide Chemistry

Dr. Laurence GRIMAUD
ENSTA, PARIS, France

12:40

Lunch & Poster session

14:00

Transition Metal Catalyzed Reactions of Carbon-Carbon and Carbon-Heteroatom Bond Formation

Prof. Irina P. BELETSKAYA
MOSCOW STATE UNIVERSITY, Moscow, Russia

14:50

The Power of Semi-Synthesis: The Discovery of Torisel ™

Dr. Jerauld S. SKOTNICKI
WYETH RESEARCH, Pearl River, United States

15:20

Synthesis and Characterisation of Novel Orally Available Dopamine D3 Receptor Antagonists

Dr. Sean TURNER
ABBOTT GMBH, LUDWIGSHAFEN, Germany

15:35

Coffee-break

16:05

A Systems Based Approach to Protein Kinase Research Leads to the Discovery of Tykerb, a Dual Inhibitor of EGFR and erbB2 Tyrosine Kinases

Dr. Wilson B. KNIGHT
GSK, Research Triangle Park, United States

16:35

The Inner Space of Molecules

Prof. Julius REBEK
SCRIPPS RESEARCH INSTITUTE, La Jolla, United States

17:25

Olefin Metathesis Catalysts for the Synthesis of Large and Small Molecules

Prof. Robert H. GRUBBS
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, United States

18:15

Closing

19:00

Symposium banquet (optional)

Following the banquet, Open bridges tour(optional)

08:30

Transfers to the airport

Optional tours between 9.00-18.00 / Canals, Petergof, Hermitage, Pushkin (Amber room) + Pavlovsk Palaces (tbc), Russian Museum (tbc)