Optional tours between 09.00-18.00 / Pushkin (Amber room) + Pavlovsk Palaces, three Cathedrals (tbc), Canals
Transfers from the airport between 12.00-19.00
Registration
Welcome reception
Opening
The Changing Face of Organic Synthesis
Prof. Steven V. LEY
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom
Protecting Group Directed Ring-Closing Metathesis (RCM): the First Total Synthesis of Anti-Malarial Nonenolide
Dr. Mukund S. CHORGHADE
CHORGHADE ENTERPRISES, NATICK, United States
Coffee-break
Discovery of Innovative Small Molecule Therapeutics
Prof Magid ABOU-GHARBIA
TEMPLE UNIVERSITY, Philadelphia, United States
The Discovery of Novel Antiviral Agents
Dr. Joe VACCA
MERCK & CO., West Point, United States
Ultra-High-Throughput Screening for Lead Discovery: Impact of Combinatorial Chemistry Compound Libraries
Dr. Stefan MUNDT
BAYER HEALTHCARE, Elberfeld, Germany
A Combinatorial Approach to Probe the Mechanism of Binding of Bivalent Ligands to GPCRs
Ms Kimberly BONGER
LEIDEN UNIVERSITY, Leiden, The Netherlands
Lunch
Polyfunctional Zn,Mg-Organometallics for Organic Synthesis
Prof. Paul KNOCHEL
LUDWIG MAXIMILIANS UNIVERSITY, Munich, Germany
Innovation in Drug Discovery and Development Interface
Dr. Balu BALASUBRAMANIAN
BRYSTOL-MYERS SQUIBB, Princeton New Jersey 08543, United States
From Adrenomedullin Positive Modulators to A New Type Of Mmp-2 Inhibitors
Prof. Beatriz DE PASCUAL-TERESA
CEU SAN PABLO UNIVERSITY, Madrid, Spain
Coffee-break
Surprises and Discoveries with Natural Products
Prof. Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland
Discovery of Bile Acid Resorption Inhibitors
Tetracyclic Indole Inhibitors of Hepatitis C Virus Ns5b-Polymerase
Dr. Ian STANSFIELD
IRBM MERCK, Pomezia Roma, Italy
Metal-Catalyzed Coupling Reactions
Prof. Gregory C. FU
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Pasadena, United States
City tour for participants
Positive and Negative Modulation of Family C GPCRs
Prof. Tanja WEIL
MERZ PHARMACEUTICALS, Ulm, Germany
New Sugar-Derived Compounds with Anti-Septic Shock, Anti-Inflammatory and Anti-Ischemia Activity
Dr. Francesco PERI
UNIVERSITY OF MILANO/BICOCCA, Milano, Italy
Coffee-break
Genomic and Nongenomic Bile Acid Receptors as New Targets for Drug Discovery
Prof. Roberto PELLICCIARI
UNIVERSITY OF PERUGIA & EFMC, Corciano, Italy
The Identification of Secretase Inhibitors for the Treatment of Alzheimer's Disease
Dr. John ELLINGBOE
WYETH RESEARCH, Pearl River, United States
Where Chemistry meets Sphingolipid Biology
Synthesis of Fosmidomycin Analogues Modified at the Three-Carbon Spacer: Towards Potent Antimalarials
Prof. Serge VAN CALENBERGH
UGENT, Ghent, Belgium
Lunch & Poster session
BUSINESS MINI SYMPOSIUM: Discovery Chemistry Outsourcing Opportunities in Russia
Opening
Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States
A Renewed Emphasis on Partnerships, With a Twist; The Challenge to Meet the Ever Evolving Pharma Landscape
Dr. Michael CLARK
PFIZER, New London, United States
Discovery Chemistry Sourcing in Russia. How Does it Compare to Other Regions of the World?
Dr. Richard D. CONNELL
PFIZER, Groton, United States
Outsourcing Parts of the Discovery Value Chain in Russia
Dr Frederik DEROOSE
JOHNSON & JOHNSON PHARMACEUTICALS, Destelbergen, Belgium
The AstraZeneca Compound Collection Enhancement Programme - Outsourcing in Russia
Dr. Garry PAIRAUDEAU
ASTRAZENECA R&D MÖLNDAL, Möndal, Sweden
Outsourcing in Russia: the UCB Experience
Dr. Patrice TALAGA
UCB, Braine-L'Alleud, Belgium
Discovery Chemistry CROs: The Art of Playing on the Fast Changing Field
Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States
Coffee-break
Panel discussion participants
B. BALASUBRAMANIAN (BMS, US), M. CLARK (Pfizer, US), R.D. CONNELL (Pfizer, US), F. DEROOSE (J&J Pharmaceuticals, Belgium), D. STOUT (Merck, US), W.B. KNIGHT (GSK, US), G. PAIRAUDEAU (AstraZeneca, UK), P. TALAGA (UCB, Belgium), G. VAISBERG (ChemBridge)
City tour for participants
New Approaches to Biologically Validated Molecules using Chemoselective Ligation Reactions
Prof. Alessandro DONDONI
UNIVERSITY OF FERRARA, Ferrara, Italy
Discovery of Aclidinium Bromide, a New Long-Acting Muscarinic Antagonist for COPD Therapy
Dr. Hamish RYDER
ALMIRALL, Barcelona, Spain
Novel Multilabeled Oligonucleotides Containing 1-phenylethynylpyrene ara-2´-uridine-carbamate and LNA: Synthesis and Photochemical Properties
Dr. Irina ASTAKHOVA
NUCLEIC ACID CENTER, DEPARTMENT OF PHYSICS AND CHEMISTRY, Odense M, Denmark
Coffee-break
Exploiting High Throughput Screening: Case Histories
Dr Paul LEESON
, Nuneaton, United Kingdom
Design and Synthesis of Thrombin Receptor Antagonists for the Prevention of Thrombosis
Dr William J. GREENLEE
SCHERING-PLOUGH RESEARCH INSTITUTE, United States
Lunch
Free afternoon - optional tours to Hermitage, Russian Museum, 3 Cathedrals and Canals
Chemical Probes of Carbohydrate Biosynthetic Pathways in Mycobacterium Tuberculosis
Prof. Laura KIESSLING
UNIVERSITY OF WISCONSIN-MADISON, Madison, United States
Discovery and Development of Kinase Iinhibitors by Targeting Conformational Switch Pockets. A General Platform that is Unique for Targeting ATP Pockets
Dr. Peter A. PETILLO
DECIPHERA PHARMACEUTICALS, Lawrence, United States
Synthesis of (±)-Cephalotaxine via Diallylboration-Ring Closing Metathesis-Bromocyclocarbamation Sequence
Dr Nikolai KUZNETSOV
INEOS RAS, Moscow, Russia
Coffee-break
SAHA (Vorinostat), an FDA Aapproved Anticancer Compound with a Novel Mechanism of Action
Prof. Ronald BRESLOW
COLUMBIA UNIVERSITY, New York, United States
The Fight Against AIDS: New Avenues for Inhibiting RT, an Old Target
Prof. Maurizio BOTTA
UNIVERSITY OF SIENA, Siena, Italy
Adventures in Medicinal Chemistry
Dr Anthony WOOD
PFIZER, Waltham, United States
Smiles Rearrangement and Isocyanide Chemistry
Dr. Laurence GRIMAUD
ENSTA, PARIS, France
Lunch & Poster session
Transition Metal Catalyzed Reactions of Carbon-Carbon and Carbon-Heteroatom Bond Formation
Prof. Irina P. BELETSKAYA
MOSCOW STATE UNIVERSITY, Moscow, Russia
The Power of Semi-Synthesis: The Discovery of Torisel ™
Dr. Jerauld S. SKOTNICKI
WYETH RESEARCH, Pearl River, United States
Synthesis and Characterisation of Novel Orally Available Dopamine D3 Receptor Antagonists
Dr. Sean TURNER
ABBOTT GMBH, LUDWIGSHAFEN, Germany
Coffee-break
A Systems Based Approach to Protein Kinase Research Leads to the Discovery of Tykerb, a Dual Inhibitor of EGFR and erbB2 Tyrosine Kinases
Dr. Wilson B. KNIGHT
GSK, Research Triangle Park, United States
Olefin Metathesis Catalysts for the Synthesis of Large and Small Molecules
Prof. Robert H. GRUBBS
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, United States
Closing
Symposium banquet (optional)
Following the banquet, Open bridges tour(optional)
Transfers to the airport
Optional tours between 9.00-18.00 / Canals, Petergof, Hermitage, Pushkin (Amber room) + Pavlovsk Palaces (tbc), Russian Museum (tbc)