Successful RNAi-Based Target Discovery Programs in a Wide Range of Human Diseases

Polypharmacology

Opening the Gate to Novel Ion Channel Modulators and Innovative Anti-arrhythmics

From Compound to Targets to Compounds: The Example of the PPARs

Lunch & poster installation

Fragment-based Drug Discovery – From Crystal to Clinic

Discovery and Optimisation of Pyrazole Inhibitors of HSP90

AstraZeneca Compound Collection Enhancement: The Synthesis of ‘Lead-Like’ Libraries

Coffee break

Synthesis and Structure-Activity Relationships of Oral Venous Antithrombotic Thioglycosylated Derivatives

Posters and wine

Closing

Speakers' reception

The Synthesis and Activity of New Inhibitors of CDK4 Based on Fascaplysin

Natural Product Inspired Isoform Selective Histone Deacetylase Inhibitors

The Evolution of a Series of Small Molecule Inhibitors of Neutral Endopeptidase

Coffee break

The Discovery of AZD0530: A Novel, Oral, Highly Selective SRC Inhibitor with BCR-ABL Activity

"Paul Ehrlich" lecture

Medicinal Chemistry: a Support to Chemical Biology and a Necessity for Drug Discovery

Lunch & posters

Sigma-Aldrich Workshop: New services for Drug Discovery by Sigma-Aldrich

This event, with presentations and discussion will run in parallel to the scientific programme

Early ADMET Tools in Drug Discovery

Biotransformation Studies in Drug Discovery Setting - Strategy, Approach and Impact

Coffee break

The Discovery and Development of a Green Process for Radafaxine

Ghrelin Ligands: from Design and Synthesis to Clinical Studies

Metathesis and Synthesis of Anticancer Agents

Posters and wine

Cocktail

Gala dinner

In Silico / Biological Fingerprinting: the Challenge of Experimental Data to Concepts of Structural and Activity Similarity and Risk Management

In Silico Predicitions of Cardiovascular Safety - Beyond hERG

Predicting Metabolic Stability for Xenobiotics

Coffee break

Long Duration of Action by Design: Discovery of Degarelix, a Self-Depoting GnRH Blocker

Concept and Development of Chimeric Molecules: Somatostatin –Dopamine Chimeras

Therapeutic proteins : Role of Post-Translational Modifications in Structure-Function Relationships. Application to Monoclonal Antibodies and Coagulation Factors

Lunch

From Medicinal Chemistry to New Targets and New Drugs. Discovery of New Antiepileptic Drug Candidates.

Diarylquinoline, a New Antibiotic, Shuts Mycobacterial Energy Supply

Discovery of Eltrombopag, a Small-Molecule Oral Thrombopoietin Receptor Agonist: a Modulator of a Protein-Protein Interaction

Closing