Workshops

On Tuesday, September 21, Waters will organise a workshop from 17:00-17:50. Complimentary drinks will be offered after the seminar to preregistered delegates - secure your place and register NOW!

Part I: Transformative Technologies for Peptide Bioanalysis
Presenter: Stephanie N. Harden, MS Business Development Manager, Waters
With approximately 400 therapeutic peptides now moving through the clinical trial process, they are fast becoming big business. Accordingly, there is a growing need for reliable, accurate, precise, reproducible, and quantitative methods for the bioanalysis of these peptides in biological fluids. However, some of the techniques currently being used are far from adequate. In this presentation we will describe a simple, straightforward Oasis® µElution SPE method development strategy for use as a basis for developing and further optimising LC/MS methods for the analysis of peptides. We will also show the significant sensitivity benefits that can be achieved when working with ACQUITY UPLC® in combination with the new Xevo™ TQ-S tandem quadrupole mass spectrometer.

Part II: Faster and More Efficient Chiral Separations with Supercritical Fluid Chromatography (SFC)
Presenter: Hélène Boiteux, SFC&Purification Business Development Manager, Waters
In the past decade, Supercritical Fluid Chromatography (SFC) has increasingly gained momentum in the pharmaceutical industry with applications that incorporate a wide variety of functional groups such as quaternary amine salts, phospholipids, vitamins, nucleosides, polypeptides, polyphenols, and surfactants. The intrinsic low viscosity and high diffusivity of supercritical carbon dioxide (CO2) has rendered SFC higher separation speed and efficiency than traditional HPLC, especially for chiral separations. In this presentation we will show the great performance of SFC when it comes to resolving structurally related compounds and isomers with greater efficiency. The significant improvement in UV detection sensitivity and its implication for method validation will also be discussed.

On Thursday, September 23 during lunch time, Thermo Fisher Scientific will organise a workshop entitled “Turnkey Solutions for Metabolite Identification and Structural Elucidation” . Registration should be made on site, at the Thermo Fisher stand.
 
Two turnkey solutions will be presented: The first one is a new software which automatically processes and reports quantitative and qualitative results based on new algorithms developed for high resolution accurate mass (HRAM) full scan data.  Such data allows for rapid DMPK analysis without specific MS methods for target compounds.  MetQuest software combined with the Exactive bench-top Orbitrap mass spectrometer enables high-throughput Quan/Qual analysis for the parent compound and its metabolites in one injection.  Also discussed is a novel software approach for metabolite detection and structural elucidation from LC-MS data using Fragment Ion Search (FISh) in conjunction with automated prediction of fragments from the parent structure.  In contrast to traditional post-acquisition processing techniques, FISh eliminates the need to predict biotransformations from the parent compound.  The site of biotransformation can be automatically localized using novel color coding of fragment ions common to the parent in the newly automated Mass Frontier 7.0.

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