5th EFMC Short Course on Medicinal Chemistry - Spring 2012

Target Selection through Application of Chemical and Systems Biology

 Castle "Oud Poelgeest", Oegstgeest, The Netherlands    April 1-4, 2012

Programme


18:00

Dinner

Introduction to Course

19:30

Drug Discovery in the Century of Systems and Chemical Biology

Dr Brian HARMS
MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States
Dr Thomas KLABUNDE
SANOFI-AVENTIS, Frankfurt am Main, Germany
20:30

Close

07:30

Breakfast

Session I: Understanding Disease Physiology

08:30

Modelling of Physiological Processes to Understand Disease

Dr Brian HARMS
MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States
Dr Thomas KLABUNDE
SANOFI-AVENTIS, Frankfurt am Main, Germany
09:00

Lost in Translation (?)

Dr Henning SCHMIDT
NOVARTIS PHARMA AG, Basel, Switzerland
09:45

Optimizing Lead Compound Selection Using Mechanistic Physiological Modeling

Dr Christina FRIEDRICH
ROSA & CO, San Carlos, United States
10:30

Coffee Break

10:45

Physiological and Disease Modelling for Diabetes: Glucose/insulin Homeostasis

Dr Thomas KLABUNDE
SANOFI-AVENTIS, Frankfurt am Main, Germany
11:00

Qualifying Mechanistic Physiological Models for Use in Pharmaceutical Discovery and Development, Part I

Dr Christina FRIEDRICH
ROSA & CO, San Carlos, United States

WORKSHOP/TUTORIAL

13:00

Lunch

14:00

Qualifying Mechanistic Physiological Models for Use in Pharmaceutical Discovery and Development, Part II

Dr Christina FRIEDRICH
ROSA & CO, San Carlos, United States
15:30

Coffee Break

Session II: Understanding Complex Biological Systems

16:00

Modelling of Cellular Systems: Helping you to Identify the Most Relevant Switches

Dr Brian HARMS
MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States
Dr Thomas KLABUNDE
SANOFI-AVENTIS, Frankfurt am Main, Germany
Prof. Julio SAEZ-RODRIGUEZ
EMBL-EBI, Heidelberg, Germany
16:45

Comparative Logical Models of Signalling Networks in Normal and Transformed Hepatocytes

Prof. Julio SAEZ-RODRIGUEZ
EMBL-EBI, Heidelberg, Germany
17:30

End day-1, followed by a social event

07:30

Breakfast

09:00

Modelling of EGFR Signalling for Target Identification

Dr Brian HARMS
MERRIMACK PHARMACEUTICALS, Cambridge, MA, United States
09:45

The Virtual Pancreatic Beta-cell: a Mod & Sim Approach in Diabetes Drug Discovery

Dr Thomas KLABUNDE
SANOFI-AVENTIS, Frankfurt am Main, Germany
10:30

Coffee Break

WORKSHOP/TUTORIAL

11:00

Models of Signalling Networks: from Coarse Boolean Approaches to Dynamic Models of Underlying Biochemistry

Prof. Julio SAEZ-RODRIGUEZ
EMBL-EBI, Heidelberg, Germany
13:00

Lunch

Session III: Target Identification by Chemical Biology

14:00

Chemical and Systems Biology Approaches for Target Identification

Dr Uwe RIX
H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, Tampa, FL, United States
14:45

Targets and Molecular Mechanisms: Charting Kinase Inhibitors in Malignant Diseases Using Chemical Proteomics

Dr Uwe RIX
H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, Tampa, FL, United States
15:30

Coffee Break

WORKSHOP/TUTORIAL

16:00

Computational Approaches to Target Prediction

Dr Thomas KLABUNDE
SANOFI-AVENTIS, Frankfurt am Main, Germany
17:00

End day-2

07:30

Breakfast

Session IV: Understand Disease Mechanisms from Transcriptomics Data and Map Disease and Drug-response Signatures

09:00

Review Tools and Case Studies for Computational Drug Repositioning

Dr Francesco IORIO
EMBL-EBI & WELLCOME TRUST SANGER INSTITUTE, Cambridge, United Kingdom
09:45

Review Computational Methods and Case Studies for Understanding Disease Mechanisms and Drug Responses

Dr Francesco IORIO
EMBL-EBI & WELLCOME TRUST SANGER INSTITUTE, Cambridge, United Kingdom
10:30

Coffee Break

WORKSHOP/TUTORIAL

11:00

Using cMap and MANTRA to identify Drug Repositioning Opportunities

Dr Francesco IORIO
EMBL-EBI & WELLCOME TRUST SANGER INSTITUTE, Cambridge, United Kingdom
12:30

Summary

13:00

Lunch and depart