Including a review of attrition rates, causes of failure and cost to the industry. To include examples of clinical attrition due to tox findings, worked examples and tutorials.

Lunch

A review of established pre-clinical and post FIH toxicity testing. To include invitro & invivo testing such as Gen Tox and functional observation; illustrated by examples and breakouts

Coffee Break

The Safety Related Attrition Challenge, including Structural Alerts:
A Medicinal Chemists Perspective of what can be controlled, including Structural Alerts; illustrated by examples and breakouts

Close

Dinner

Molecular Properties
Physicochemical properties and toxicology outcome, including Med Chem risk; including worked examples and breakouts

Coffee Break

Including druggability, linking the target to the disease and the importance of understanding Ceff

Lunch

Ion Channel Safety:
Ion channel basics; their general roles in physiology; ion channel families and sub-types; their pharmacology in the context of drug safety; ion channel assays and screens; illustrated by case studies and worked examples

Coffee Break

Role of transporter interactions in toxicology and attrition:
Transporter interactions that have been linked to toxicity, e.g. kidney, liver (BSEP). Mechanisms and consequences. In vitro tools and predictive strategies; illustrated by case studies and worked examples

Close

Dinner

Focusing on Cyp inhibition, idiosyncratic toxicity, including reactive metabolites, time dependent inhibition; PK variability and can earlier and rapid PK assessment & insilico prediction methods reduce attrition

Coffee Break

Characterising Mechanisms of toxicity
Including pathway mining and investigative pathology type approaches to elucidating mechanisms

Lunch

Course ends