SPICA 2012

International Symposium on Preparative and Industrial Chromatography and Allied Techniques

 Brussels, Belgium    September 30

Programme


13:00

Registration

14:00

Start of parallel sessions

Workshop 1
Workshop 2
Workshop 3
Workshop 1
14:00
Preparative HPLC : Phase Screening, Method Optimization, Process Development. Troubleshooting a Preparative Chromatographic Device
Dr Michael SCHULTE
MERCK, Darmstadt, Germany
Workshop 2
14:00
From Development to Commercial Scale: Rules to Scale up, QbD, Regulatory, Process Validation
Dr Alessandro BUTTE
ETH ZURICH, Zurich, Switzerland
Workshop 3
14:00
Multicolumn Processes: from Historical SMB to the Latest Advances in the Purification of Biomolecules
Prof. Arvind RAJENDRAN
UNIVERSITY OF ALBERTA, Edmonton, AB, Canada
15:30

Coffee Break

16:00

Start of parallel sessions

Workshop 4
Workshop 5
Workshop 6
Workshop 4
16:00
Solving a Purification Process: Choice of the Appropriate Process (Batch vs Continuous, Low Pressure vs High Pressure, Liquid vs SFC, Centrifugal Partition Chromatography vs Countercurrent Chromatography)
Dr Eric VALERY
NOVASEP CDMO, AN AXPLORA COMPANY, Pompey, France
Workshop 5
16:00
Process Design for Purification of Small Molecules
Prof. Jochen STRUBE
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
Workshop 6
16:00
Process Design for Purification of Biomolecules
Prof. Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES, Vienna, Austria
18:00

Welcome reception

09:00

Welcome

Session 1: Quality by Design

Session Chair

Prof. Massimo MORBIDELLI
ETH ZÜRICH, Milano, Italy
09:20

Quality by Design in API Purifications. Making the Right Things

Dr Alessandro BUTTE
ETH ZURICH, Zurich, Switzerland
10:00

Quality by Design with Rigorous Process Modeling as Platform Technology of the Future

Mr Christoph HELLING
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
10:20

A Model Based Approach to Reducing the Analytical Burden of High Throughput Screening

Dr Marcus DEGERMAN
LUND UNIVERSITY, Lund, Sweden
10:40

Characterization of Adsorption in SFC: an Evaluation of Methods Used in LC

Prof. Torgny FORNSTEDT
KARLSTAD UNIVERSITY, Karlstad, Sweden
11:00

Coffee Break

Session 2: Multicolumn Chromatography

Session Chair

Dr Eric FRANCOTTE
NOVARTIS, Nuglar, Switzerland
11:30

Experimental Study on a Binary Chromatographic System Subject to a Mixed Competitive-Cooperative Adsorption Isotherm

Mr Simon JERMANN
ETH ZÜRICH, Zurich, Switzerland
11:50

Relay SMB: A Simple and Efficient Way of Implementing Simulated Moving-Bed Chromatography

Prof. José Paulo MOTA
REQUIMTE/CQFB, FFCT, Caparica, Portugal
12:10

Model Mismatch Resolution and Optimization for Simulated Moving Bed and Continuous Chromatographic Processes

Prof. Yoshiaki KAWAJIRI
GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States
12:30

Lunch, Vendor Seminar (Novasep, Waters, Phenomenex, Knauer)

Session 3: Innovative Production Technologies

Session Chair

Prof. Andreas SEIDEL-MORGENSTERN
MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany
Prof. Tuomo SAINIO
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland
14:00

Biological Production of Peptides

Prof. Susanna LEONG
NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, Singapore
14:40

Nanofiltration of Peptides in Acetonitrile/Water Mixtures: Process Development

Ms Patrizia MARCHETTI
LONZA, Visp, Switzerland
15:00

Efficient API Purification or How Combining OSN and Chromatography Increases Your Process Yields!

Dr Muriel NASSO
EVONIK, Wembley, United Kingdom
15:20

Separation of Bionanoparticles and Biological Superstructures

Prof. Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES, Vienna, Austria
15:40

Coffee Break

Session 4: Fundamentals

Session Chair

Prof. Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND APPLIED LIFE SCIENCES, Vienna, Austria
16:10

Molecular Engineering of Multiple Weak Interactions for High Selectivity Bioseparations

Prof. Steven CRAMER M
RENSSELAER POLYTECHNIC INSTITUTE, Troy, United States
16:50

Modeling of Protein Aggregation in Preparative Chromatography

Prof. Bernt NILSSON
LUND UNIVERSITY, Lund, Sweden
17:10

Modeling Protein Adsorption Equilibria on Ion-Exchange Resins

Dr Bertrand GUELAT
NOVARTIS PHARMA AG, Basel, Switzerland
17:30

Distributed Pore Surface Model

Ing Niklas BORG
LUND UNIVERSITY, Lund, Sweden
17:50

Study of Hydrodynamics in Chromatographic Columns by Computed X-Ray Tomography and its Evaluation by CFD Simulations

Ms Irma SCHMIDT
UNIVERSITY ERLANGEN-NUREMBERG, Erlangen, Germany
18:10

Poster Session #1

07:00

Young Scientist Breakfast

Session 5: Green Technology - Complex Continuous Resolution

Session Chair

Prof. Arvind RAJENDRAN
UNIVERSITY OF ALBERTA, Edmonton, AB, Canada
Dr Svetlana IGNATOVA
BRUNEL UNIVERSITY, Uxbridge, United Kingdom
08:50

Preparative Chiral Chromatography: What Can Go Wrong and How to Solve it

Dr Pilar FRANCO
CHIRAL TECHNOLOGIES, INC, Illkirch, France
09:10

Supercritical Fluids as the Desorbent for Simulated Moving Bed? Application to the Concentration of Triterpenoids from Taiwanofugus Camphorate

Ms Liang RU CHIEN
I SHOU UNIVERSITY, Kaohsiung City, Taiwan
09:30

Optimization of Simulated Moving Bed Processes for Multicomponent Chiral Separations

Dr António E. RIBEIRO
POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal
09:50

A Non-Conventional Application of Simulated Moving Bed Technology: Purification of a Complex Mixture

Ms Kiara KOCHENDOERFER
UNIVERSITY ERLANGEN-NUREMBERG, Ludwigshafen, Germany
10:10

Coffee Break

Session 6: Partitioning and Extraction

Session Chair

Prof. Joachim KINKEL
GEORG-SIMON-OHM UNIVERSITY OF APPLIED SCIENCES, Nuernberg, Germany
10:40

Liquid-Liquid Extraction of Biomolecules - Process Development and Integration into Downstream Processing

Mr Jan Kristof EGGERSGLUESS
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal, Germany
11:00

Design Of Tailor-Made Stationary And Mobile Phase In Liquid-Liquid Chromatography

Prof. Mirjana MINCEVA
UNIVERSITÄT ERLANGEN, Freising, Germany
11:20

Towards Optimally Sized Centrifugal Partition Chromatography Columns - Process Design Methodology and Applications

Mr Sebastien CHOLLET
GEPEA LABORATORY, Saint-Nazaire, France
11:40

Scalable Technology for the Extraction of Pharmaceuticals (STEP): Progress on Developing Versatile Small Footprint Technology for Continuous Processing at the Lab Scale up to 1 Kg/Day

Prof. Ian SUTHERLAND
BRUNEL INSTITUTE FOR BIOENGINEERING, Uxbridge, United Kingdom
Dr Svetlana IGNATOVA
BRUNEL UNIVERSITY, Uxbridge, United Kingdom
12:00

Lunch, Vendor Seminar (Kromasil, Merck Millipore, PIC Solution and Chiral Technologies)

Session 7: Process Integration 1 - Isomeric Separation

Session Chair

Dr Shalini ANDERSSON
ASTRAZENECA, Mölndal, Sweden
Prof. Mirjana MINCEVA
UNIVERSITÄT ERLANGEN, Freising, Germany
13:30

Implementation of a Continuous Chromatography Step in The Synthesis of an API – Combining Chemistry and Chromatography to Achieve Better Economics

Dr Olivier DAPREMONT
SK PHARMTECO, Rancho Cordova, United States
14:10

Continuous Synthesis and Purification Through Direct Combination of a Flow Reactor and Simulated Moving Bed Chromatography

Dr Ju Weon LEE
MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany
14:30

Integrated Chromatographic Processes for the Production of Pure Enantiomers

Prof. Malte KASPEREIT
FRIEDRICH-ALEXANDER UNIVERSITY ERLANGEN-NÜRNBERG, Erlangen, Germany
14:50

From Racemate to Single Enantiomer with 100% Yield by Process Integration of SMB and Enzymatic Racemization

Mr Markus FUEREDER
ETH ZURICH, Basel, Switzerland
15:10

Coffee Break sponsored by AMPAC Fine Chemicals

Session 8: Process Integration 2 - Food and Products

Session Chair

Dr Eric VALERY
NOVASEP CDMO, AN AXPLORA COMPANY, Pompey, France
Prof. Malte KASPEREIT
FRIEDRICH-ALEXANDER UNIVERSITY ERLANGEN-NÜRNBERG, Erlangen, Germany
15:40

New Approaches to Food Fractionation by Chromatography: Adapting High-Cost Techniques to the Production of Moderate-Value Products

Prof. Conan FEE
UNIVERSITY OF CANTERBURY, Christchurch, New Zealand
16:20

A Reaction-Separation Integrated Process for the High-Yield Synthesis of Rare Sugars

Ms Nina WAGNER
ETH ZURICH D-BSSE, Basel, Switzerland
16:40

Chromatographic Process Options for Reduced Purities

Prof. Tuomo SAINIO
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland
17:00

Model Based Design and Integration of Crystallization Processes of Natural Products in Down Stream Processing

Mr Iraj KOUDOUS
INSITUT FÜR THERMISCHE VERFAHRENS- UND PROZESSTECHNIK, Clausthal-Zellerfeld, Germany
17:20

Special Symposium - Rountable Discussion: Process Integration and Intensification

Dr Olivier DAPREMONT
SK PHARMTECO, Rancho Cordova, United States
Dr Eric VALERY
NOVASEP CDMO, AN AXPLORA COMPANY, Pompey, France
Dr Shalini ANDERSSON
ASTRAZENECA, Mölndal, Sweden
18:00

Poster Session 2

20:00

Gala Dinner

Session 9: SMB and Novel Chromatography Approaches

Session Chair

Prof. José Paulo MOTA
REQUIMTE/CQFB, FFCT, Caparica, Portugal
08:50

Enabling High Purities and Yields in Therapeutic Peptide Purification by Using Continuous Chromatography (MCSGP)

Dr Thomas MÜLLER-SPÄTH
CHROMACON AG, Zurich, Switzerland
09:10

Continuous Purification of Single-Chain Antibody Fragments by Simulated Moving Bed Chromatography

Mr Carlos Andres MARTINEZ CRISTANCHO
MAX-PLANCK-INSTITUT MAGDEBURG, Magdeburg, Germany
09:30

Integration of Hydrophobic Interaction- and Ion Exchange Chromatography

Mr Tim WELLSANDT
INSITUT FÜR THERMISCHE VERFAHRENS- UND PROZESSTECHNIK, Clausthal-Zellerfeld, Germany
09:50

Purification of Proteins from Human Blood Plasma by Multicolumn Solvent Gradient Purification

Mr Daniel BAUR
ETH ZÜRICH, Zurich, Switzerland
10:10

Poster Prize

10:30

Coffee Break

Session 10: Affinity Ligands and Biopharmaceuticals

Session Chair

Prof. Jochen STRUBE
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
11:00

Molecular Modeling of the Affinity Chromatography of Proteins: Status and Perspectives

Prof. Carlo CAVALLOTTI
POLITECNICO DI MILANO, Milano, Italy
11:40

Peptidomimetic Affinity Ligands (PALs) - A Powerful Approach to Improving DSP Performance

Dr Matthias PASCHKE
3B PHARMACEUTICALS GMBH, Berlin, Germany
12:00

New Trend in Material Development for Peptide Purification

Dr Nicola FORRER
ZEOCHEM, Uetikon am See, Switzerland
12:20

A New Disposable Technology for Chromatographic Purification of Biopharmaceuticals

Dr David YAVORSKY
MERCK-MILLIPORE, Bedford, United States
12:40

Shifting the Scale-up Limits of Disposable Downstream Processing

Mr. Marcel RAEDTS
PROXCYS BV, Nieuw Amsterdam, The Netherlands
13:00

Closing Remarks