4th International Symposium on Advances in Synthetic and Medicinal Chemistry
St. Petersburg, Russia August 21-25, 2011
Tour 1: Pavlovsk and Pushkin
09:00-16:00
Tour 2: Petergof
10:00-17:00
Tour 3: Hermitage
14:00-18:00
Registration
Tour 4: Boat Trips (Canals)
15:00-18:00
Welcome Reception
Session Chair
Opening
Maitotoxin. An Inspiration for Synthesis
Tofacitinib (CP-690,550): Discovery of a Potent and Selective JAK Inhibitor
Coffee Break and Exhibition
A few of my Favorite Rings: Catalysis Inspired by Lactones and Lactams
Small Molecules Inhibitors of the WNT Signalling Pathway with Potential Applications in Oncology
Lunch and Exhibition
Session Chair
Drug Discovery by Programmed Self-Assembly
The Many Uses of Noncovalent Mass Spectrometry in Early-stage Drug Discovery
Small Molecule Inhibitors of the Neuropilin-1 VEGF-A Interaction
Lead identification of a new class of P2Y12 inhibitors "From a low active and insoluble HTS hit to soluble and active lead compounds"
Coffee Break, Exhibition and Posters
GPR119: Knowledge Based Lead Identification
Regioselective Reactions on a Chiral Substrate Controlled by the Configuration of a Chiral Catalyst
Closing of the Day
City Tour for Participants
Session Chair
Synthesis of Marine Polyketides as Promising Anticancer Agents
Chemical Probes for Epigenetics
The Chemical Biology Consortium- and Experimental Therapeutics Program
Coffee Break, Exhibition and Posters
Design Strategy for Preparation of Drug-like Polyheterocycles with Privileged Substructures for Discovery of Specific Small Molecule Modulators
Bromodomains a New Class of Epigenetic Targets Ripe for Small Molecule Drug Discovery
Identification of Leads from the Tres Cantos Antimalarial Set: Cyclopropyl Carboxamides Show Good Oral Bioavailability and Efficacy In Malarial Animal Models
Lunch and Exhibition
Poster Session 1
Session Chair
Minor Enantiomer Recycling – A Strategy for Improving Enantioselectivity
Antibody Directed Cytotoxics
Exploring the Rigid Mono- and Diamine Chemical Space
Highly Efficient Catalytic System for C-H Activation: A Novel and Practical Synthesis of Angiotensin II Receptor Blockers
Coffee Break, Exhibition and Posters
Bicyclic Peptides with Tailored Binding Specificities for Therapeutic Application
Adventures in Medicinal Chemistry and Knowledge Capture
Target Synthesis Directed Methodology Development
Closing of the Day
From Homer to Hedgehog: Chemistry, Biological Investigations and Medical Perspectives of Cyclopamine
Biochemical Efficiency, a Metrics for an Optimal Molecular Mechanism of Action
Identification of Bisaryloxy Azetidine Urea Derivatives as Fatty Acid Amide Hydrolase Inhibitors
Coffee Break, Exhibition and Posters
Lessons in Chemoselectivity: Total Synthesis of Polyphenolic Natural Products
The Resurgence of Covalent Drugs
Halogen Bonding in Protein–ligand Interactions
Lunch and Exhibition
Poster Session 2
Free Afternoon
Tour 5: Hermitage
14:30-18:30
Tour 6: Canals
15:00-18:00
Validation of N-Myristoyltransferase as a Drug Target
Novel Metabotropic Glutamate Receptor 4 (mGluR4) Allosteric Potentiators for the Treatment of Parkinsons’s Disease
The Chemistry of Targeting Protein-Protein Interactions: Thinking Outdside of the Box
Coffee Break, Exhibition and Posters
Asymmetric Synthesis of Bioactive Molecules
A Step Closer to Hepatitis C Remedy: TMC435, an HCV Protease Inhibitor in Advanced Clinical Trial
The Grandisine Alkaloids as Selective δ-Opioid Receptor Agonists; When is a Natural Product not a Natural Product?
Lunch and Exhibition
Session Chair
Discovery and Development of Novel Antimalarials
Accelerated C-H Activation Reactions: Enantioselectivity and Positional Selectivity
Coffee Break and Exhibition
Metal-Catalyzed C–H Bond Functionalizations for Sustainable Synthesis
Magical Power of d-Block Transition Metals—Pd-Catalyzed Cross-Coupling and Zr-Catalyzed Asymmetric carboalumination of Alkenes (ZACA)
Closing Remarks
Symposium Banquet
Tour 7: Pavlovsk-Pushki
09:00-18:00
Tour 8: Petergof
10:00-17:00