RICT 2011 - Drug Discovery and Selection

A Brief Guide to Fluorine-Protein Interactions for the Medicinal Chemist

How can Computers Support Drug Discovery? In Silico Approaches for Anticipating Bioactivity Spectra, Analysing Adverse Drug Reactions and Predicting Ligand Activity Against Particular Protein Mutants

The Design, SAR and Synthesis of Novel ADAM-TS4 (Aggrecanase-1) Inhibitors for the Treatment of Osteoarthritis

Synthesis of Radiolabelled Probes for Positron Emission Tomography: The Link Between Molecular Imaging and Medicinal Chemistry

Template Assembled Functional Biomolecules : Chemistry, Characterization and Validation as a Paradigm for Tailor Made Molecular Medicine

Proteomic Studies as a Guide in the Development of New Cyclin-dependent Kinase Inhibitors

Discovery and Lead Optimisation of a Novel Series of Highly Potent, Selective and Orally Bioavailable SYK Inhibitors

Folding Oligomers with Predictable Structures and Properties

Accessing Libraries of Highly Antitumor Active Ansamycin Antibiotics by Semi- and Mutasynthesis

The Mitotic Kinesin Eg5 as a Target for Drug Development in Cancer Chemotherapy: from Inhibitor Screening to in vivo Models

Fragment-based Engineering of Protein-ligand Interactions Using NMR and Other Biophysical Methods : Towards Tailor-made Drugs

Discovery and Optimization of Kinase Inhibitors: Some Case Studies from GKS3β and IGF1R Inhibitors

Ehrlich Lecture - Title to be announced

Difluoromethylbenzoxazole (DFMB)Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Gut-Targeted Microsomal Triglyceride Transfer Protein Inhibitors to Treat Obesity: Design, Clinical Proof of Concept and Novel Chemical Leads

Discovery of Riociguat: A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

Aleglitazar, a Potent and Balanced Dual PPARα/γ Agonist for the Reduction of Cardiovascular Mortality and Morbidity in Patients with Type 2 Diabetes

New Multivalent Glyco-vaccines: Molecular Engineering of the Regiospecificity of Transglucosidases for Chemo-enzymatic Oligosaccharide Synthesis

Mentzer Lecture - DNA-Encoded Chemical Libraries: a New Tool for Drug Discovery

KCC2 : a New Target for Epilepsy?

Discovery of Potent and Selective Smoothened Inhibitors for the Treatment of Hedgehog-dependent Tumors

Development of Enantiomers: the Example of Chiral Sulfoxides

Tumor Targeting Using Shiga Toxin: Syntheses and Biological Evaluations of Some Conjugates

A Journey in Data and Chemical Spaces: Application to Pharmaceutical Sciences

Non-Denaturing Chemical Proteomics for Protein Complex Isolation and Identification