Het Pand, Ghent, Belgium October 14-15, 2010
Registration, poster set-up and welcome coffee
Conference Opening and Welcome Address
Welcome Address
Session Chair
Keynote Address: Raymond Hamers
From Whole Monoclonal Antibodies to Single Domain Antibodies: Think small
Discovery of Camelid Heavy-chain Only Antibodies and Generation of Nanobodies
Coffee Break and Poster Viewing
Overview of Ig-NARs and Generation of V-NARs
Session Chair
Single Domain Antibodies Targeting the BBB and the Brain Vasculature
Cell Penetrating Anti-GFAP VHH Spontaneously Cross the BBB and Specifically Recognizes Astrocytes
Networking Lunch and Poster Viewing
A Nanobody targeting the N-terminal alpha-helical Multimerization Domain of HIV-1 Rev prevents Viral Production
A Novel and Unique Method to introduce Nanobodies Inside a Cell
Session Chair
Lactobodies: Lactobacilli Expressing Variable Domain of Llama Heavy-chain Antibody Fragments (Lactobodies) Confer Protection against Rotavirus-induced Diarrhea.
Engineering of Aggregation-resistant Human Antibody Domains by Phage Display
Pulmonary Delivered Domain Antibodies: anti-TNFR1 dAb for Lung Diseases
Coffee Break and Poster Viewing
Session Chair
OC 1 - Inhibition of Actin Filament Capping by a CapG SDA restrains Cellular Migration and Invasion
OC2 - Development of SDA against the HIV-1 ENV Glycoprotein to inhibit Infection of CD4+ Cells
OC 3 - ART-2 Blocking Nanobodies Protect Regulatory T Cells from NAD-induced Cell Death
OC 4 - Analysis of BBB Permeablity for Nanobodies using Microdialysis
Closing Remarks from Co-Chairs
Networking Drink with Lite Bites
Session Chair
Improved Tumor Targeting of Anti-EGFR Nanobodies through Albumin Binding
Engineering Nanobodies for Improved Treatment of Infectious Diseases
Using dAbs to Control in Vivo Exposure of Metabolic Peptides
Session Chair
Inhibitory and Stimulatory Nanobodies Against a Nucleotide-gated Ion Channel
Coffee Break and Poster Viewing
CXCR4-specific Nanobodies Selectively and Potently Inhibit Chemotaxis and HIV Entry
'Engineering Nanobodies that Bind to Human Lysozyme and Inhibit its Conversion to Amyloid Fibrils: Prospects in Systemic and Neurodegenerative Protein Aggregation Diseases
Llama Single Domain Antibodies as Rugged Countermeasures for Filoviruses and BoNT
Networking Lunch and Poster Viewing
Nanobodies with G protein like properties stabilize a G Protein-Coupled Receptor Active State
Session Chair
Connecting Biochemistry and Cell Biology with Nanobodies
Molecular Imaging using Nanobodies
Session Chair
Considerations for the Manufacture of Nanobodies from Pipeline into the Clinic
Nanobodies: Roadmap to Clinical Proof of Concept. Review of Phase I Experience.
Closing Remarks from the Co-Chairs
Presentation of the Young Scientist Awards & Closure of the Symposium