Single Domain Antibodies Come of Age

 Het Pand, Ghent, Belgium    October 14-15, 2010

Programme


08:30

Registration, poster set-up and welcome coffee

09:15

Conference Opening and Welcome Address

Prof. Serge MUYLDERMANS
VUB-VIB, Brussels, Belgium
Dr Hilde REVETS
ABLYNX, Antwerpen , Belgium
09:30

Welcome Address

Dr Edwin MOSES
CEO, ABLYNX, Ghent, Belgium

Session 1: The Rise of Single-Domain Antibodies

Session Chair

Prof Martin FLAJNIK
UNIVERSITY OF MARYLAND, Baltimore, United States
09:35

Keynote Address: Raymond Hamers

Prof. Serge MUYLDERMANS
VUB-VIB, Brussels, Belgium
Dr Hilde REVETS
ABLYNX, Antwerpen , Belgium
10:00

From Whole Monoclonal Antibodies to Single Domain Antibodies: Think small

Dr Jean-Luc TEILLAUD
CENTRE DE RECHERCHE DES CORDELIERS UNIVERSITÉ PIERRE ET MARIE CURIE PARIS 6, Paris, France
10:30

Discovery of Camelid Heavy-chain Only Antibodies and Generation of Nanobodies

Prof. Serge MUYLDERMANS
VUB-VIB, Brussels, Belgium
11:00

Coffee Break and Poster Viewing

11:20

Overview of Ig-NARs and Generation of V-NARs

Prof Martin FLAJNIK
UNIVERSITY OF MARYLAND, Baltimore, United States

Session 2: Crossing the Barriers: BBB and Membranes, Intracellular Targeting

Session Chair

Dr Danica STANIMIROVIC
INSTITUTE FOR BIOLOGICAL SCIENCES, Ottawa, Ontario, Canada
11:50

Single Domain Antibodies Targeting the BBB and the Brain Vasculature

Dr Danica STANIMIROVIC
INSTITUTE FOR BIOLOGICAL SCIENCES, Ottawa, Ontario, Canada
12:20

Cell Penetrating Anti-GFAP VHH Spontaneously Cross the BBB and Specifically Recognizes Astrocytes

Dr Pierre LAFAYE
INSTITUT PASTEUR PARIS, Paris, France
12:50

Networking Lunch and Poster Viewing

14:00

A Nanobody targeting the N-terminal alpha-helical Multimerization Domain of HIV-1 Rev prevents Viral Production

Dr Dirk DAELEMANS
REGA INSTITUTE FOR MEDICAL RESEARCH, Leuven, Belgium
14:30

A Novel and Unique Method to introduce Nanobodies Inside a Cell

Dr Luis Angel FERNÁNDEZ-HERRERO
CENTRO NACIONAL DE BIOTECNOLOGIA, Madrid, Spain

Session 3: Alternative Delivery of Single Domain Antibodies

Session Chair

Dr Daniel CHRIST
GARVAN INSTITUTE OF MEDICAL RESEARCH, Sydney, Australia
15:00

Lactobodies: Lactobacilli Expressing Variable Domain of Llama Heavy-chain Antibody Fragments (Lactobodies) Confer Protection against Rotavirus-induced Diarrhea.

Prof. Lennart HAMMARSTRÖM
KAROLINSKA INSTITUTE, Stockholm, Sweden
15:30

Engineering of Aggregation-resistant Human Antibody Domains by Phage Display

Dr Daniel CHRIST
GARVAN INSTITUTE OF MEDICAL RESEARCH, Sydney, Australia
16:00

Pulmonary Delivered Domain Antibodies: anti-TNFR1 dAb for Lung Diseases

Dr Peter MORLEY
GLAXOSMITHKLINE, Stevenage, United Kingdom
16:30

Coffee Break and Poster Viewing

Session 4: Selected Abstracts for Oral Presentation

Session Chair

Prof. Serge MUYLDERMANS
VUB-VIB, Brussels, Belgium
16:50

OC 1 - Inhibition of Actin Filament Capping by a CapG SDA restrains Cellular Migration and Invasion

Dr katrien VAN IMPE
UGENT, Gent, Belgium
17:10

OC2 - Development of SDA against the HIV-1 ENV Glycoprotein to inhibit Infection of CD4+ Cells

Ms Julie MATZ
INSERM, marseille, France
17:30

OC 3 - ART-2 Blocking Nanobodies Protect Regulatory T Cells from NAD-induced Cell Death

Mr Björn RISSIEK
UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF, Hamburg, Germany
17:50

OC 4 - Analysis of BBB Permeablity for Nanobodies using Microdialysis

Dr Ralph CLINCKERS
VUB, Jette - Brussel, Belgium
18:10

Closing Remarks from Co-Chairs

18:20

Networking Drink with Lite Bites

Session 5: Engineering Single Domain Antibodies for Improved Function

Session Chair

Prof. Guus VAN DONGEN
VU AMSTERDAM, Amsterdam, The Netherlands
09:00

Improved Tumor Targeting of Anti-EGFR Nanobodies through Albumin Binding

Prof. Guus VAN DONGEN
VU AMSTERDAM, Amsterdam, The Netherlands
09:30

Engineering Nanobodies for Improved Treatment of Infectious Diseases

Dr Michiel HARMSEN
CENTRAL VETERINARY INSTITUTE OF WAGENINGEN, Lelystad, The Netherlands
10:00

Using dAbs to Control in Vivo Exposure of Metabolic Peptides

Dr Laurent JESPERS
GSK, Cambridge, United Kingdom

Session 6: Targeting Less Accessible Antigens Including Certain Membrane-associated Proteins, Enzymes, Ion Channels and G-protein Coupled Receptors that weave in and out Cell Surfaces

Session Chair

Dr Friedrich KOCH-NOLTE
INSTITUTE OF IMMUNOLOGY, UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF, Hamburg, Germany
10:30

Inhibitory and Stimulatory Nanobodies Against a Nucleotide-gated Ion Channel

Dr Friedrich KOCH-NOLTE
INSTITUTE OF IMMUNOLOGY, UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF, Hamburg, Germany
11:00

Coffee Break and Poster Viewing

11:20

CXCR4-specific Nanobodies Selectively and Potently Inhibit Chemotaxis and HIV Entry

Prof. Martine SMIT
VU AMSTERDAM, Amsterdam, The Netherlands
11:50

'Engineering Nanobodies that Bind to Human Lysozyme and Inhibit its Conversion to Amyloid Fibrils: Prospects in Systemic and Neurodegenerative Protein Aggregation Diseases

Dr Mireille DUMOULIN
UNIVERSITY OF LIÈGE, Liège, Belgium
12:20

Llama Single Domain Antibodies as Rugged Countermeasures for Filoviruses and BoNT

Dr Andrew HAYHURST
SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH, San Antonio, United States
12:50

Networking Lunch and Poster Viewing

13:30

Nanobodies with G protein like properties stabilize a G Protein-Coupled Receptor Active State

Prof. Jan STEYAERT
VUB-VIB, Brussels, Belgium

Session 7: Imaging Applications of Single Domain Antibodies

Session Chair

Dr Hilde REVETS
ABLYNX, Antwerpen , Belgium
14:00

Connecting Biochemistry and Cell Biology with Nanobodies

Dr Tina ROMER
LMU MÜNCHEN, Martinsried, Germany
14:30

Molecular Imaging using Nanobodies

Dr Tony LAHOUTTE
VUB, Brussels, Belgium

Session 8: Single Domain Antibodies in the Clinic

Session Chair

Dr Josi HOLZ
CMO, ABLYNX, Ghent, Belgium
15:00

Considerations for the Manufacture of Nanobodies from Pipeline into the Clinic

Dr Ann BRIGÉ
ABLYNX, Zwijnaarde, Belgium
15:30

Nanobodies: Roadmap to Clinical Proof of Concept. Review of Phase I Experience.

Dr Josi HOLZ
CMO, ABLYNX, Ghent, Belgium
16:00

Closing Remarks from the Co-Chairs

16:15

Presentation of the Young Scientist Awards & Closure of the Symposium

Dr Edwin MOSES
CEO, ABLYNX, Ghent, Belgium