EFMC 2nd Short Course on Medicinal Chemistry

Safety and Attrition

 Oegstgeest, The Netherlands    April 11-14, 2010

Programme Schedule


18:00

Dinner

19:30

Introduction to Safety & Attrition Workshop

Dr Alan STOBIE
PFIZER, Sandwich, United Kingdom
21:00

Close

08:30

General Overview of Current Safety and Toxicity Testing

Dr Dominic WILLIAMS
UNIVERSITY OF LIVERPOOL, Liverpool, United Kingdom
10:30

Coffee Break

11:00

Small Molecule Based Attrition (1) - Structural 'Alerts'

Dr Julian BLAGG
THE INSTITUTE OF CANCER RESEARCH, United Kingdom
12:30

Lunch

13:30

Small Molecule Based Attrition (2) - Molecular Properties

Dr Julian BLAGG
THE INSTITUTE OF CANCER RESEARCH, United Kingdom
15:30

Tea Break

16:00

Off-Target Based Attrition (1) - Ion Channel Safety

Dr Chris POLLARD
ASTRAZENECA, Macclesfield, United Kingdom
18:00

Close

19:30

Dinner

08:30

Off-Target Based Attrition (2) - Role of Transporter Interactions in Toxicology and Attrition

Dr Gerry KENNA
ASTRAZENECA, Macclesfield, United Kingdom
10:00

Coffee Break

10:30

Admet or DMPK Based Attrition

Dr Don WALKER
PFIZER, Sandwich, United Kingdom
12:30

Lunch

13:30

Choosing the Right Target

Dr Alan STOBIE
PFIZER, Sandwich, United Kingdom
13:30

Attrition (3) - Insilico Prediction Methods

Dr Alan STOBIE
PFIZER, Sandwich, United Kingdom
14:30

The Safety and Attrition Game

18:00

Close

19:30

Dinner

08:30

Newer Methods of Predicting Toxicity (1) - Characterising Mechanisms of Toxicity

Dr Mark M. GOSINK
PFIZER, Groton, United States
10:00

Coffee Break

10:30

Newer Methods of Predicting Toxicity (2) - Use of Whole Cell Invitro Methods

Dr Jim DYKENS
PFIZER, Sandwich, United Kingdom
12:30

Lunch

13:30

Course Ends