Remark:
Poster Session 1 = odd numbers
Poster Session 2 = even numbers
Registration
Welcome reception
Opening
Session Chair
The Metalated Flatland Conduit to New Synthetic Aromatics and Heteroaromatic Chemistry
C-H Activation: Direct Arylation and Alkenylation of Oxazoles
Coffee-break
Orally Active, Brain Penetrant Beta-Secretase (BACE) Inhibitors: Consolidating Property-Based and Structure-Based Drug Design
From Structures to Systems: Structure Based Design of Therapeutics and Imaging Probes
Structure-Activity Relationships and Cancer-Cell Selective Toxicity Of Novel Inhibitors of Glioma-Associated Oncogene Homolog 1 (Gli1)-Mediated Transcription
Molecular Recognition at the Active Site of Catechol-O-Methyl Transferase (COMT): Energetically Favorable Expulsion of a Single Water Molecule with Novel Bisubstrate Inhibitors.
Lunch and Poster Session 1
Bio-Inspired Organocatalysis: From Concepts to Applications in Heterocycle Synthesis
Discovery of Ixempratm (ixabepilone), an Epothilone Analogue for Treatment of Metastatic Breast Cancer
Design and Synthesis of Novel Polyketide Molecular Frameworks to Access Natural Product-Like Protein-Protein Interaction Inhibitors as Novel Chemotherapeutic Agents
Coffee-break and Poster Session 1
Compound Collection Enhancement (CCE): Increasing Quality and Size of the AZ Compound Collection
Approach to the Synthesis of Pycnanthuquinone C by Gold(I)-Catalyzed Cyclization of 1,5-Enynes
C-H: A New Functional Group for Streamlining Synthesis
Closing of the day
Session Chair
Development and Applications of New Metal-Catalyzed Carbon-Carbon Bond Forming Reactions
Case Histories of Fragment Based Discovery: from Crystal to Clinic
Design and synthesis of polyfluoroalkyl-containing purine isosters and phospha-purines as a potential Adenosine Deaminase (ADA) and Inosine 5’-monophosphate dehydrogenase (IMPDH) inhibitors
Coffee-break and Poster Session 1
The Fight against AIDS. The "Old" Reverse Transcriptase (RT) and the "New" DDX3
Targeting Protein-Protein Interactions: Bcl-2 Family Protein Inhibitors to Treat Cancer
Discovery Biology Fueled with Synthetic Chemicals
Lunch & Poster session 1
Afternoon Session: Business Mini-Symposium
Session Chair
Compound Screenings in Model Plants to Identify New Agrochemicals: Strengths and Limitations
Creating a medicinal chemistry created screening library
Optimization of a Small Molecule Screening Library to support HTS Campaigns Across Diverse Therapeutic Areas and Target Classes
Strategies Toward The Establishment and Evolution of a CNS Focused Small Molecule Screening Collection
Small Molecule Screening Libraries in Drug Discovery: Today & Tomorrow
JHICC - When Vast Chemical Diversity Meets Ion Channel Targets
Coffee-break
Navigating the NIH Roadmap - Building a Screening Collection for Discovery of Biological Probes
Kinase Inhibitors in Compound Collection of Life Chemicals
Chemically Validated Combinatorial Approach to Large Libraries of Individual Drug Like Compounds
Scaffold-based Libraries: It’s design and applications
Out-Sourcing Of Small Molecule Screening Libraries: Lessons From The Past, View Into The Future
Q & A
Closing of the day
Session Chair
The Chemistry of DNA Repair and DNA Lesion Tolerance
Design of BCR-Abl Kinase Inhibitors to Treat Imatinib-Resistant Leukaemia
SQUIRRELnovo: De Novo Design of a PPARalpha Agonist by Bioisosteric Replacement
Coffee-break
Discovery of PF-610355: An Inhaled Once-daily Beta-2 Adrenoceptor Agonist for Asthma & COPD
Discovery of NVP-BEZ235, a New Anti-Cancer Drug Candidate Targeting the PI3K/Akt/mTOR Pathway
Conformational Restriction as a Design Concept for Unnatural Amino Acids
Directed Evolution of Enzymes: New Biocatalysts for Organic Synthesis'
Lunch and Poster Session 2
Free afternoon
Session Chair
A Small Molecule with a Big Impact: Inspirations from Proline Catalysis
The Structure Based Design of Potent, Selective BACE1 Inhibitors as Potential Disease Modifying Treatments for Alzheimer's Disease
Chiral Imidates: A New Class of Nitrogen-Based Chiral Ligands.
Coffee-break and Poster Session 2
Orexin Receptor Antagonists – A New Therapeutic Principle in CNS Disorders?
Guanidinium Toxins: Unique Natural Products in both Form and Function
Cation–Pi Interactions in the S4 Pocket of Factor Xa: Dramatic Enhancement upon N-Alkylation of Ammonium Ions
Lunch and Poster Session 2
Small Molecule Drug Discovery in the Modern World
Synthesis of Fluorine Containing Amino Acids with Biological Interest
Building Molecular Complexity via Gold Catalysis
Coffee-break
The Discovery of the Oral Antifungal Agent Albaconazole: a Case History
New Catalytic Strategies for Chemical Synthesis
Closing Remarks
Symposium banquet