Oegstgeest, near Leiden, The Netherlands, March 22-25, 2009
Dinner
Introduction to compound quality
Coffee
Importance of physical chemical drug properties: pKa, lipophilicity, solubility
Lunch
Tea
Basics of QSAR modeling
Dinner
In silico ADMET
Coffee
Estimation of oral absorption and bioavailability
Lunch
Importance of adequate pharmacokinetics: F, A, Vd, CL, t1/2, ppb
Tea
DMPK assays and their interpretation for drug design teams
Dinner
Prediction of drug metabolism
Coffee
Role of drug metabolism and transporters in drug design: assays, technologies, interpretation
Basic knowledge on drug metabolism (reactions, enzymes), reactive metabolites, factors affecting drug metabolism, mDDI, prodrug design
Lunch
Course end