EFMC Short Course - Improving Compound Quality:
Physical Chemistry and DMPK Properties in Drug Discovery. Principles, Assays and Predictions

 Oegstgeest, near Leiden, The Netherlands, March 22-25, 2009    

Programme


18:00

Dinner

08:30

Introduction to compound quality

Dr. Han VAN DE WATERBEEMD
, Saint Andre, France
10:00

Coffee

10:30

Importance of physical chemical drug properties: pKa, lipophilicity, solubility

Dr Andy DAVIS
ASTRAZENECA, Mölndal, Sweden
12:30

Lunch

13:30

Measurement of physchem properties

Dr. Barbara MASON
PHYSCHEM CONSULTING, United Kingdom
15:00

Tea

15:30

Basics of QSAR modeling

Dr Andy DAVIS
ASTRAZENECA, Mölndal, Sweden
19:30

Dinner

08:30

In silico ADMET

Dr. Han VAN DE WATERBEEMD
, Saint Andre, France
10:00

Coffee

10:30

Estimation of oral absorption and bioavailability

Dr. Han VAN DE WATERBEEMD
, Saint Andre, France
12:00

Lunch

13:30

Importance of adequate pharmacokinetics: F, A, Vd, CL, t1/2, ppb

Dr Don WALKER
PFIZER, Sandwich, United Kingdom
15:00

Tea

15:30

DMPK assays and their interpretation for drug design teams

Dr Don WALKER
PFIZER, Sandwich, United Kingdom
19:30

Dinner

08:30

Prediction of drug metabolism

Prof. Bernard TESTA
UNIVERSITY HOSPITAL CENTRE, Lausanne, Switzerland
10:00

Coffee

10:30

Role of drug metabolism and transporters in drug design: assays, technologies, interpretation

Dr. Chris KOHL
ACTELION, Allschwill, Switzerland
12:00

Basic knowledge on drug metabolism (reactions, enzymes), reactive metabolites, factors affecting drug metabolism, mDDI, prodrug design

Prof. Bernard TESTA
UNIVERSITY HOSPITAL CENTRE, Lausanne, Switzerland
13:00

Lunch

14:00

Course end