Experiences in Fragment-based Lead Discovery
SPR Biosensor-Based Fragment Screening and Lead Characterization
Novel-Generation Kinase Inhibitors: Deep Pocket Binders by Fragment- Based Design
Coffee-break
The Use of Acetylcholine Binding Protein and FBDD Approaches in the Quest for Novel Nicotinic Receptor Ligands.
Oral Communications
Fragment-Based Identification of Novel Hsp90 Inhibitors
Searching the Impossible – Designing Libraries from Large Virtual Chemistry Spaces
Lunch
Discovery And Development Of Selective, Orally Bioavailable Tyrosine Kinase Inhibitors For Targeted Treatment Of Human Cancers
Non-Competitive Inhibitors of MEK1: from Discovery to the Clinic
The Discovery and Development of Allosteric Akt Inhibitors for the Treatment of Cancer
Coffee-break
Oral Communications
Understanding Kinase Selectivity Through Active Site Hydration Energetics
4-Aryl-7-Azaindoles as IKK2 Inhibitors
Targeted Kinase Inhibitors : Precision in Interaction and Efficacy
Poster Session
End of Scientific Programme
Dinner
Structural Genomics of GPCRs; New Opportunities for Drug Discovery
GPCR Hetero-Dimerisation: Contribution to Receptor Pharmacology and Function
Discovery & Development of Allosteric Modulators: Hopes and Promises
Coffee-break
Oral Communications
The 2.6 Angstrom Crystal Structure of a Human a2a Adenosine Receptor Bound to an Antagonist
Fieldstere: Application to the Discovery of 5-HT1D Agonists
Transmembrane Helix Position 5.48 Involvement in the Dimer Interface Of Domain-Swapped GPCRS
Lunch and Poster Session
Histamine H4 Antagonists as Future Anti-Inflammatory Drugs
JAK3 Kinase: a Molecular Target for Treatment of Inflammatory Diseases and Renal Transplant Rejection
Molecular Mechanim of Action for Chemokine and Other Anti-inflammatory Agents on 7TM Receptors
Coffee-break
Oral Communications
The Quest for the New Antihistamines: Discovery and Evaluation of Histamine H4 Receptor Ligands
Developing CCR5 Antagonists for HIV: the Story since Maraviroc
Discovery of Novel Small Molecule CXCR4 Antagonists
End of Scientific Programme (participants are requested to remove their posters)
Dinner
Concert
Engineering of Proteins and Peptides to Tailor Structure–Function and Pharmacokinetic
Sugars and Proteins
CarboCarrier(TM): a Novel Technology to Extend the Half-life of Small Proteins and Peptides
Coffee-break
Oral Communications
Role of Sugar Moieties in Biological Activities of Glycopeptide Antibiotics of the Vancomycin and Teicoplanin Group
Miniproteins Targeting the Nuclear Receptor – Coactivator Interaction
Conjugation of Synthetic Peptides to Toll-Like Receptor Ligands for Vaccine Development
Lunch
Excursion (dinner included)
Predicting Substrate Properties for ABC-Transporter - Safety Sciences on the Molecular Level
Drug Transport and Metabolism: Value of Knockout and Transgenic Mouse Models
Insights from Structural Studies of Human ATP-Binding Cassette Drug Transporters
Coffee-break
Novel Approaches for Comprehensive Profiling of Metabolites in Lead Discovery: Integration of Screening Assays with Ion-trap Time of Flight Mass Spectrometry
Oral Communication
Non-Covalent Mass Spectrometry Screening Technology: An “ESI” Approach to Support Drug Discovery
Lunch
GPCR Antitargets – Prediction and Prevention of Side Effects
Understanding Ion Channels Using Computational Approaches
The QSARome of the Receptorome: Development of Robust QSAR Models Capable of Predicting Compound Binding Profiles against Multiple Targets
Coffee-break
Oral Communications
Erythromycin Analogs - More Than Just Antibacterials
Mining A Global Literature Pharmacology Knowledgebase to Assess Drug Polypharmacology of Classical Chemical Scafolds
Between Prometheus and Morpheus: Identifying Histamine Receptor Selectivity Switches
End of the programme
Symposium Banquet