Interfacing Chemical Biology, Natural Products and Drug Discovery
02/07/2008
08:30
Registration of participants & Introduction Accueil des participants & Introduction
Session 1 From Natural Products to Drug Discovery Des produit naturels à la découverte de médicaments
Prof. Pascal RICHOMME (UNIVERSITÉ D'ANGERS, Angers, France)
09:30
New Approaches for the Search of New Bioactive Compounds from Higher Plants
Prof. Kurt HOSTETTMANN (UNIVERSITÉ DE GENÈVE SCIENCES II, Genève, Switzerland)
10:15
Marine Metabolites as Pharmacophores and Biomedical Research Tools
Prof. Marcel JASPARS (UNIVERSITY OF ABERDEEN, Old Aberdeen, United Kingdom)
11:00
Elucidating New Pathways for Natural Product Biosynthesis and Exploiting them for Drug Discovery
Prof. Gregory L. CHALLIS (UNIVERSITY OF WARWICK, Coventry, United Kingdom)
12:00
Lunch and Poster
Repas et installation des communications par affiches
Dr. Michel VAULTIER (UNIVERSITÉ DE RENNES 1, RENNES Cedex, France)
13:30
From a Plant to a Drug Candidate S 23906 and Acronycin Derivatives - Illustration of the Complementarity of Industrial and Academic Approaches
Prof. François TILLEQUIN (UNIVERSITÉ PARIS DESCARTES, Paris, France)
From a Plant to a Drug candidate S 23906 and Acronycin derivatives
Illustration of the complementarity of industrial and academic approaches
Dr. Bruno PFEIFFER (INSTITUT DE RECHERCHES SERVIER, Croissy sur Seine, France)
14:15
Venomics – Targeted Drug Discovery in Animal Venoms
Dr. Reto STÖCKLIN (ATHERIS LABORATORIES, Geneva, Switzerland)
15:00
Poster Session
Communications par affiches
Session 2 Natural Products Synthesis Synthèse de produits naturels
Dr. Michael D. THREADGILL (UNIVERSITY OF BATH, Bath, United Kingdom)
15:30
Recent Advances in the Total Synthesis of Bioactive Natural Products
Prof. Tony BARRETT (IMPERIAL COLLEGE, London, United Kingdom)
16:15
Mimicking "Nature Diversity-Oriented Synthesis": the Manzamine Family of Marine Alkaloids
Dr. Christian MARAZANO (INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES, Gif-sur-Yvette, France)
17:00
Synthetic, Structural and Biosynthetic Studies on Mupirocin (Pseudomonic Acid) Biosynthesis
Prof. Tom SIMPSON (UNIVERSITY OF BRISTOL, Bristol, United Kingdom)
18:45
Reception at Hôpital St. Jean offered by the municipality of Angers (including a visit of the Apocalypse by Jean Lurçat Réception à l'Hôpital St. Jean offerte par la municipalité d'Angers (avec un visite de l'Apocalypse de Jean Lurçat
03/07/2008
Session 3 Challenging Targets and Approaches Cibles et approches défiantes
Prof. Gerard DÉLÉRIS (UNIVERSITE DE BORDEAUX, Bordeaux, France)
08:45
Chromenone- and Pyranone-Based Inhibitors of DNA Damage-Activated Kinases as Antitumour Agents
Prof. Roger J. GRIFFIN (NEWCASTLE UNIVERSITY, Newcastle upon Tyne, United Kingdom)
09:30
"Prix Charles Mentzer" Development and Biological Evaluation of Prodrugs for a Selective Treatment of Cancer
Prof. Lutz F. TIETZE (GEORG-AUGUST-UNIVERSITÄT, Göttingen, Germany)
10:15
Coffee break Pause café
10:35
P-Glycoprotein - from Inhibitor Design to Substrate Prediction
Prof. Gerhard ECKER (EFMC, UNIVERSITY OF VIENNA, Vienna, Austria)
11:20
Targeting DNA and Protein-Protein Interactions
Dr. Mark SEARCEY (UNIVERSITY OF EAST ANGLIA, Norwich, United Kingdom)
12:15
Mini-Session
Chemical Biology, Life Sciences and Drug Discovery: How to Promote "Cross-Talks"?
Prof. Gerard DÉLÉRIS (UNIVERSITE DE BORDEAUX, Bordeaux, France) Dr Yves ROLLAND (SOCIÉTÉ DE CHIMIE THÉRAPEUTIQUE, Châtenay-Malabry, France)
12:45
Lunch
Repas
Career Opportunities Session from 14:00 to 15:30 Session carrières de 14h à 15h30
Dr. Robert H. DODD (ICSN CNRS, Gif-Sur-Yvette, France)
13:45
Chemical Diversity and Biotransformation: Metabolomics Based Approaches
Mr. Bernard WALTHER (TECHNOLOGIE SERVIER, Orleans, France)
14:30
Inhibitors of Heterotrimeric G-Protein Signalling: A New Strategy for Anti Cancer Therapy
Dr. Grégoire PREVOST (GROUP IPSEN, Les Ulis, France)
15:15
Poster Session Ciommunications par affiches
Session 4 Tools and Approaches Outils et apporches
Prof. Tom SIMPSON (UNIVERSITY OF BRISTOL, Bristol, United Kingdom)
16:00
Finding New Biologically Active Natural Products via HTS: Reality or Utopia
Dr. Delphine JACQUOT (MERCK KGAA, Darmstadt, Germany)
16:45
High Thoughput Physicochemical Profiling in Drug Discovery - Equilibria and Dynamics
Dr. Richard TAYLOR (UCB, Slough, United Kingdom)
17:30
ADME/Tox: a New Tool for Medicinal Chemistry
Dr. Christian FILAQUIER (CENTRE DE RECHERCHE PIERRE FABRE, Castres, France)
Gala Dinner at "Greniers St. Jean" Dîner de gala aux Greniers St. Jean
04/07/2008
Session 5 Tools and Approaches Outils et approches
Prof. Janos SAPI (UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, REIMS cedex, France)
08:45
Approaches to the Design of Kinase Inhibitors by Molecular Modeling
Dr. Pascal FURET (NOVARTIS PHARMA INC, Basel, Switzerland)
09:30
"Paul Ehrlich" Lecture Some Recent Advances in Drugs and Nanomaterials Development for Therapeutical Applications
Dr Frédéric TARAN (CEA/SACLAY, Gif-sur-Yvette, France)
10:15
Coffee break Pause café
Prof. Marcel JASPARS (UNIVERSITY OF ABERDEEN, Old Aberdeen, United Kingdom)
10:35
A Multidisciplinary Approach Leading to the Discovery of a Novel RSV Fusion Inhibitor
Dr Jean-François BONFANTI (TIBOTEC, A DIVISION OF JANSSEN-CILAG, Val de Reuil, France)
11:20
Identification of activin-like kinase 5 (ALK5) inhibitors for the treatment of fibrosis: chronicle of a toxicity foretold
Dr. Françoise GELLIBERT (SERVIER, Suresnes Cedex, France)
12:15
Lunch
Repas
Session 6 Carbohydrates Hydrates de carbone
Dr Luc VAN HIJFTE (JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT, Beerse, Belgium)
13:45
From Automated Oligosaccharide Synthesis to a Malaria Vaccine
Dr. Bastien CASTAGNER (ETH, Zürich, Switzerland)
14:30
Design, Synthesis and Properties of SSR126517E, a Biotinylated Antithrombin Pentasaccharide
Dr. Gilbert LASSALLE (SANOFI-AVENTIS, Toulouse, France)
