LD Organisation

Scientific Conference Producers

Program


13:00

Registration
The registration desk will remain open during the whole symposium.

17:30

Welcome Reception
From 17:30 - 18:30, in the hall of the Mezhdunarodnaya Hotel.

08:30

Opening

09:20

Perspectives in Total Synthesis

Prof. K.C. NICOLAOU
THE SCRIPPS RESEARCH INSTITUTE, Houston, United States
10:20

Coffee break

10:45

Biomimetic Oxidations of Organic Substrates

Prof. Jan-Erling BÄCKVALL
STOCKHOLM UNIVERSITY, Stockholm, Sweden
11:35

Studies on Bioactive Macrocycles: New Concepts and Spin-offs

Prof. Alois FÜRSTNER
MAX PLANCK INSTITUT FUR KOHLENFORSCHUNG, Muelheim an der Ruhr, Germany
12:25

Lunch

13:45

"IN SILICO" Design and Focused Synthesis of New Neuroactive Compounds in the Series of Glutamate Receptors Ligands

Prof. Nikolay S. ZEFIROV
INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS, Moscow, Russia
14:35

Biomimetic Synthesis

Prof. Sir Jack BALDWIN
UNIVERSITY OF OXFORD, OXFORD, United Kingdom
15:25

Coffee break

15:50

Catalytic Asymmetric Synthesis of Pharmaceuticals

Prof. Masakatsu SHIBASAKI
UNIVERSITY OF TOKYO, Tokyo, Japan
16:40

Drug Discovery - Back to the Future

Prof. K. Barry SHARPLESS
THE SCRIPPS RESEARCH INSTITUTE, LA JOLLA,, CA, United States
19:30

BANQUET
Buffet dinner at the Presidency of the Academy of Science.

08:30

Challenges in Drug Discovery: Design and Synthesis of Novel Drug Candidates

Prof Magid ABOU-GHARBIA
TEMPLE UNIVERSITY, Philadelphia, United States
09:05

Application of Enabling Technologies to Expedite Drug Discovery

Dr Mark DUGGAN
LINK MEDICINE CORPORATION, Cambridge, United States
09:30

Designing Selective Kinase Inhibitors: Tools, Concepts, Challenges and Opportunities

Dr Serge HALAZY
SERONO INTERNATIONAL S.A., GENEVE, Switzerland
09:55

Electrophilic Fluorodesilylation of Organosilanes a New Synthetic Route to Various Fluorinated Compounds

Prof. Véronique GOUVERNEUR
UNIVERSITY OF OXFORD, Oxford, United Kingdom
10:05

Coffee break

10:35

Design and Synthesis of Enzyme Inhibitors - From Concepts to Practice

Prof. Stephen HANESSIAN
UNIVERSITY OF MONTREAL, MONTREAL, QC, Canada
11:25

Indoline and Indolenine Intermediates in the Syntheses of Complex Indole Derivatives

Prof. Maria PREOBRAZHENSKAYA
GAUSE INSTITUTE OF NEW ANTIBIOTICS, MOSCOW, Russia
11:35

Molecular Diversity from Acylnitroso Cycloadditions: Preparation of Novel Scaffolds and Focused Targets

Prof. Marvin MILLER
UNIVERSITY OF NOTRE DAME, NOTRE DAME, IN, United States
11:45

ViagraTM & Beyond: Selective PDE5 Inhibitors for Treatment of MED

Dr Mark BUNNAGE
PFIZER, Boston, United States
12:10

Application of Chemogenomic Principles to Library and Template Design

Dr Thomas R. WEBB
CHEMBRIDGE CORPORATION, SAN DIEGO, United States
12:35

Lunch

13:45

Structure-Based Design of Nonpeptidic Enzyme Inhibitors: Molecular Recognition Studies with Biological Receptors

Prof. François DIEDERICH
ETH ZURICH, Zürich, Switzerland
14:35

SAR By XRay: A New Approach Combining Screening and Rational Drug Design. Application to the Discovery of Nanomolar Src SH2 Binders

Dr Dominique LESUISSE
SANOFI AVENTIS, Chilly-Mazarin, France
15:00

Molecular Design, Chemical Synthesis and Biological Evaluation of Quinoxaline-Carbohydrate Hybrids as Novel and Selective Photo-Induced Dna Cleaving and Cytotoxic Agents

Prof. Kazunobu TOSHIMA
KEIO UNIVERSITY, YOKOHAMA, Japan
15:10

Coffee break

15:40

From Synthetic Polyelectrolites to Vaccinating Macromolecules

Prof. Viktor A. KABANOV
RUSSIAN ACADEMY OF SCIENCES, Russia
16:30

Arene-Arene Interactions Between the Substrate and the Organocatalyst as the Driving Force In the Asymmetric Allylation of Aldehydes with Allyltrichlorosilanes.

Dr Andrei MALKOV
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom
16:40

Asymmetric Approach to Proline-Derived Spiro-Β-Lactams - Staudinger Reaction of N-Protected-4-Methanesulfonyloxy-L-Proline with N-Aryl Imines

Dr Mohan THIRUVAZHI
CHEMBRIDGE RESEARCH LABORATORIES, SAN DIEGO, United States
16:50

Hit and Lead Generation - Beyond High Throughput Screening

Dr Alexander ALANINE
INDEPENDANT RESEARCHER, Cambridge, United Kingdom
19:00

Optional:
Swan Lake Ballet at the Bolshoï Theater

21:30

Moscow by night guided tour (First departure)

22:00

Moscow by night guided tour (Second departure)

08:30

Synthesis and Pharmacological Characterization of Novel Epothilone Derivatives

Dr Rainer METTERNICH
CAPROTEC BIOANALYTICS, Basel, Switzerland
09:05

The Discovery of BIBN4096, a Novel CGRP Antagonist for the Treatment of Migraine

Prof. Dr. Gerd SCHNORRENBERG
BOEHRINGER INGELHEIM PHARMA KG, Biberach an der Riss, Germany
09:30

The Synthesis of Biarylthioether derivatives as GlyT1 Inhibitors

Dr Garrick SMITH
H. LUNDBECK A/S, VALBY, Denmark
09:55

Catalytic Synthesis of Azoles, or Teaching an Old Dog New Tricks

Prof. Valery FOKIN
THE SCRIPPS RESEARCH INSTITUTE, LA JOLLA, United States
10:05

Coffee break

10:35

New Multicomponent Reactions

Prof. Nicos A. PETASIS
UNIVERSITY OF SOUTHERN CALIFORNIA, LOS ANGELES, United States
11:25

Computer-Aided Discovery of New Pharmacological Agents With Multiple Mechanisms Of Action

Prof. Vladimir POROIKOV
INSTITUTE OF BIOMEDICAL CHEMISTRY OF RUS. ACAD. MED. SCI., Moscow, Russia
11:35

Dysinosins B – D, Inhibitors Of Factor Viia And Thrombin From The Australian Sponge Lamellodysidea Chlorea

Dr Malcolm BUCHANAN
GRIFFITH UNIVERSITY, BRISBANE, QUEENSLAND, Australia
11:45

LMW Agonists for the Human LH Receptor: Identification, Optimisation and Mechanism of Action

Dr Marco TIMMERS
ORGANON, OSS, The Netherlands
12:10

Solution Phase Combinatorial Chemistry: Enabling Technologies for Heterocyclic Synthesis

Dr Larry TRUESDALE
PFIZER, LA JOLLA, United States
12:35

Lunch

13:45

Research Collaborations and Technology Integration

Dr Michael T. CLARK
PFIZER, NEW LONDON, United States
14:10

Compound Collection Enhancement Activities in AstraZeneca

Dr Mike T. COX
, HOLMES CHAPEL, Cheshire, United Kingdom
14:35

Developing and Managing Discovery Chemistry Collaborations

Mr Steven HUTCHINS
MERCK & CO., RAHWAY, United States
15:00

Coffee break

15:15

The Impact of Out-sourcing on R&D Productivity

Dr Jay MCGILL
LILLY, INDIANAPOLIS IN, United States
15:40

Chemical Outsourcing: Beyond Routine Work

Dr. Patrice TALAGA
UCB, Braine-L'Alleud, Belgium
16:05

10 Years of Discovery Chemistry Outsourcing in Russia: From Compound Acquisition to Strategic Research Collaborations

Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States
19:30

OPERA PERFORMANCE at NEW OPERA THEATER

08:30

Progress in the Total Synthesis of Polycyclic Natural Products

Prof. Johann MULZER
UNIVERSITY OF VIENNA, Vienna, Austria
09:20

The Construction of the Chiral Quaternary Carbon in Drug Discovery Directed towards the Novel Neuroprotective Agent E2050

Dr Teiji KIMURA
EISAI CO. LTD, IBARAKI, Japan
09:45

Fluorinated Azaheterocycles in Medicinal Chemistry

Prof. Valeri Nikolaevich CHARUSHIN
URAL TECHNICAL UNIVERSITY, EKATERINBURG, Russia
10:35

Coffee break

11:05

Polycycles from Polyenes, Seeking Opportunities for Organic Synthesis

Prof. Erik SORENSEN
PRINCETON UNIVERSITY, Princeton, United States
11:55

Tris-(2-Hydroxyethyl) Ammonium Salts of Aryl Heteroacetic Acids – New Class of Drugs And Biologically Active Compounds

Prof. Anna MIRSKOVA
FAVORSKII INSTITUTE OF CHEMISTRY, IRKUTSK, Russia
12:05

Practical Considerations in Predicting ADMET Properties from Chemical Stucture

Dr Scott BOYER
ASTRAZENECA, Barcelona, Spain
13:00

Lunch

14:00

KREMLIN GUIDED TOUR

19:00

Optional:
Evgeny Onegin at the Bolchoï Theater

09:00

Optional:
TOUR 1 Tretiakov Galery + Cathedral of Christ the Saviour

09:00

Optional:
TOUR 2 Pushkin Museum + Cathedral of Christ the Saviour